Sulfotransferase Expression - Implications for Toxicity

Runge-Morris, Melissa A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29ES005823-05
• Application #: 2154703
• Study Section: Toxicology Subcommittee 2 (TOX)
• Project Start: 1992-03-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1998-02-28
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Wayne State University
• Type: Organized Research Units
• City: Detroit
• State: MI
• Country: United States
• Zip Code: 48202

Publications

Fu, Jiaqi; Fang, Hailin; Paulsen, Michelle et al. (2011) Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells: role of the aryl hydrocarbon receptor. J Pharmacol Exp Ther 339:597-606

Bai, Qianming; Xu, Leyuan; Kakiyama, Genta et al. (2011) Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. Atherosclerosis 214:350-6

Fu, Jiaqi; Weise, Amy M; Falany, Josie L et al. (2010) Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression. Breast Cancer Res Treat 120:35-45

Cook, Ian T; Duniec-Dmuchowski, Zofia; Kocarek, Thomas A et al. (2009) 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. Drug Metab Dispos 37:2069-78

Duniec-Dmuchowski, Zofia; Fang, Hai-Lin; Strom, Stephen C et al. (2009) Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Drug Metab Dispos 37:900-8