The objective of this study is to determine if DNA bending induced by binding of the human ER plays a role in transcription activation of E- responsive genes.
Aim l is to determine if the effectiveness of ER in DNA bending is influenced by E, salt activation, or phosphorylation.
Aim 2 is to determine if unoccupied ER, ER occupied by E, and ER occupied by antiE bend DNA in the same direction.
Aim 3 is to determine if the extent of DNA bending induced by the ER correlates with the magnitude of gene transcription activation by the ER.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
First Independent Research Support & Transition (FIRST) Awards (R29)
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Biochemical Endocrinology Study Section (BCE)
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Yoshinaga, Koji
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University of Illinois Urbana-Champaign
Schools of Arts and Sciences
United States
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