Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL044727-05
Application #
2221662
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-08-01
Project End
1997-07-31
Budget Start
1995-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Adamko, D J; Yost, B L; Gleich, G J et al. (1999) Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects. J Exp Med 190:1465-78
Costello, R W; Evans, C M; Yost, B L et al. (1999) Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. Am J Physiol 276:L709-14
Costello, R W; Fryer, A D; Belmonte, K E et al. (1998) Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs. Br J Pharmacol 124:267-76
Jacoby, D B; Xiao, H Q; Lee, N H et al. (1998) Virus- and interferon-induced loss of inhibitory M2 muscarinic receptor function and gene expression in cultured airway parasympathetic neurons. J Clin Invest 102:242-8
Costello, R W; Schofield, B H; Kephart, G M et al. (1997) Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol 273:L93-103
Belmonte, K E; Jacoby, D B; Fryer, A D (1997) Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs. Br J Pharmacol 121:1287-94
Fryer, A D; Costello, R W; Yost, B L et al. (1997) Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways. J Clin Invest 99:2036-44
Evans, C M; Fryer, A D; Jacoby, D B et al. (1997) Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs. J Clin Invest 100:2254-62
Okanlami, O A; Fryer, A D; Hirshman, C (1996) Interaction of nondepolarizing muscle relaxants with M2 and M3 muscarinic receptors in guinea pig lung and heart. Anesthesiology 84:155-61
Kahn, R M; Okanlami, O A; Jacoby, D B et al. (1996) Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung. J Clin Invest 98:299-307

Showing the most recent 10 out of 19 publications