Adrenergic receptors play a major role in cardiovascular reactivity but have been largely neglected in reactivity studies. This study examines the association of beta- and alpha-adrenergic receptors, in combination with cardiovascular and neurohormonal measures, with cardiovascular reactivity. The study will follow two phases. Phase 1. Forty healthy male subjects will be exposed to a primarily beta-adrenergic stressor (public speaking) and a primarily alpha-adrenergic stressor (mirror star tracing). Heart rate, cardiac output, peripheral resistance, and blood pressure reactivity will be measured. We will then assess the association between these reactivity measures and resting measures of lymphocyte beta-adrenergic and platelet alpha-adrenergic receptor density and function, plasma norepinephrine and epinephrine, blood pressure, heart rate, cardiac output, and peripheral resistance. Subjects will be re-studied 6 weeks later in order to examine the test-retest stability of this relationship Phase 2. This phase of the study further examines the stability of the receptor-reactivity relationship. We will study subjects where adrenergic receptors and reactivity naturally undergo cyclic variation. Using the phase 1 protocol, forty normal cycling women will be tested twice: once during the follicular phase and once during the luteal phase of the menstrual cycle. This data will be compared to the data from phase 1 of the study. Keywords: adrenergic receptors, cardiovascular, behavioral medicine, stress, sympathetic nervous system, catecholamines, menstrual cycle, sex differences.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HL047074-01
Application #
3473632
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1991-08-16
Project End
1996-07-31
Budget Start
1991-08-16
Budget End
1992-07-31
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gonzalez-Trapaga, J L; Nelesen, R A; Dimsdale, J E et al. (2000) Plasma epinephrine levels in hypertension and across gender and ethnicity. Life Sci 66:2383-92
Mills, P J; Berry, C C (1999) Menstrual cycle, race and task effects on blood pressure recovery from acute stress. J Psychosom Res 46:445-54
Mills, P J; Ziegler, M G; Morrison, T A (1998) Leptin is related to epinephrine levels but not reproductive hormone levels in cycling African-American and Caucasian women. Life Sci 63:617-23
Mills, P J; Ziegler, M G; Rehman, J et al. (1998) Catecholamines, catecholamine receptors, cell adhesion molecules, and acute stressor-related changes in cellular immunity. Adv Pharmacol 42:587-90
Nelesen, R A; Dimsdale, J E; Mills, P J et al. (1996) Altered cardiac contractility in sleep apnea. Sleep 19:139-44
Mills, P J; Nelesen, R A; Ziegler, M G et al. (1996) Menstrual cycle effects on catecholamine and cardiovascular responses to acute stress in black but not white normotensive women. Hypertension 27:962-7
Nelesen, R A; Dimsdale, J E; Mills, P J et al. (1995) Relationship of insulin, race, and hypertension with hemodynamic reactivity to a behavioral challenge. Am J Hypertens 8:12-9
Mills, P J; Dimsdale, J E; Nelesen, R A et al. (1994) Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge. Psychosom Med 56:70-6
Fukuzawa, J; Osaki, J; Haneda, T (1994) Differential effects of amiloride on the basal rate and the pressure overload-induced increase in protein synthesis in perfused rat heart. Clin Exp Hypertens 16:835-52
Mills, P J; Dimsdale, J E; Nelesen, R A et al. (1994) Cyclic AMP export from lymphocytes in hypertension. Clin Exp Hypertens 16:825-33

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