Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
3R35CA044257-07S1
Application #
2091409
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1988-07-01
Project End
1996-11-30
Budget Start
1994-07-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Stassinopoulos, A; Ji, J; Gao, X et al. (1996) Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog. Science 272:1943-6
Gao, Q; Cheng, X; Smith, R D et al. (1996) Binding specificity of post-activated neocarzinostatin chromophore drug-bulged DNA complex studied using electrospray ionization mass spectrometry. J Mass Spectrom 31:31-6
Yang, C F; Stassinopoulos, A; Goldberg, I H (1995) Specific binding of the biradical analog of neocarzinostatin chromophore to bulged DNA: implications for thiol-independent cleavage. Biochemistry 34:2267-75
Xu, Y J; Xi, Z; Zhen, Y S et al. (1995) A single binding mode of activated enediyne C1027 generates two types of double-strand DNA lesions: deuterium isotope-induced shuttling between adjacent nucleotide target sites. Biochemistry 34:12451-60
Gao, X; Stassinopoulos, A; Gu, J et al. (1995) NMR studies of the post-activated neocarzinostatin chromophore-DNA complex. Conformational changes induced in drug and DNA. Bioorg Med Chem 3:795-809
Zeng, X; Xi, Z; Kappen, L S et al. (1995) Double-stranded damage of DNA.RNA hybrids by neocarzinostatin chromophore: selective C-1' chemistry on the RNA strand. Biochemistry 34:12435-44
Stassinopoulos, A; Goldberg, I H (1995) Binding and cleavage characteristics of the complexes formed between the neocarzinostatin chromophore and single site containing oligonucleotides. Bioorg Med Chem 3:713-21
Stassinopoulos, A; Goldberg, I H (1995) Probing the structure of long single-stranded DNA fragments with neocarzinostatin chromophore. Extension of the base-catalyzed bulge-specific reaction. Biochemistry 34:15359-74
Gao, X; Stassinopoulos, A; Rice, J S et al. (1995) Structural basis for the sequence-specific DNA strand cleavage by the enediyne neocarzinostatin chromophore. Structure of the post-activated chromophore-DNA complex. Biochemistry 34:40-9
Kappen, L S; Goldberg, I H (1995) Bulge-specific cleavage in transactivation response region RNA and its DNA analogue by neocarzinostatin chromophore. Biochemistry 34:5997-6002

Showing the most recent 10 out of 34 publications