Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA049731-06
Application #
2093410
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1991-04-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Poppers, D M; Schwenger, P; Vilcek, J (2000) Persistent tumor necrosis factor signaling in normal human fibroblasts prevents the complete resynthesis of I kappa B-alpha. J Biol Chem 275:29587-93
Alpert, D; Vilcek, J (2000) Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells. J Biol Chem 275:10925-9
Goodman, A R; Levy, D E; Reis, L F et al. (2000) Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages. J Leukoc Biol 67:387-95
Alpert, D; Schwenger, P; Han, J et al. (1999) Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation. J Biol Chem 274:22176-83
Gerecitano, J; Perle, M A; Vilcek, J (1999) Transcriptional basis for the differences in inducible nitric oxide synthase (iNOS) expression between nonmetastatic and metastatic murine melanoma cell lines. J Interferon Cytokine Res 19:393-405
Schwenger, P; Alpert, D; Skolnik, E Y et al. (1999) Cell-type-specific activation of c-Jun N-terminal kinase by salicylates. J Cell Physiol 179:109-14
Wisniewski, H G; Vilcek, J (1997) TSG-6: an IL-1/TNF-inducible protein with anti-inflammatory activity. Cytokine Growth Factor Rev 8:143-56
Schwenger, P; Bellosta, P; Vietor, I et al. (1997) Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Proc Natl Acad Sci U S A 94:2869-73
Wisniewski, H G; Hua, J C; Poppers, D M et al. (1996) TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol 156:1609-15
Wisniewski, H G; Naime, D; Hua, J C et al. (1996) TSG-6, a glycoprotein associated with arthritis, and its ligand hyaluronan exert opposite effects in a murine model of inflammation. Pflugers Arch 431:R225-6

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