Immunochemistry of Group B Streptococcal Polysaccharides

Kasper, Dennis L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AI023339-12
• Application #: 2062149
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1985-09-01
• Project End: 1997-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 12
• Fiscal Year: 1996

Institution

• Name: Brigham and Women's Hospital
• DUNS #: 071723621
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Baker, Carol J; Carey, Vincent J; Rench, Marcia A et al. (2014) Maternal antibody at delivery protects neonates from early onset group B streptococcal disease. J Infect Dis 209:781-8

Wang, Julia Y; Chang, Alex H C; Guttormsen, Hilde-Kari et al. (2003) Construction of designer glycoconjugate vaccines with size-specific oligosaccharide antigens and site-controlled coupling. Vaccine 21:1112-7

Paoletti, Lawrence C; Kasper, Dennis L (2003) Glycoconjugate vaccines to prevent group B streptococcal infections. Expert Opin Biol Ther 3:975-84

Pozdnyakova, Olga; Guttormsen, Hilde-Kari; Lalani, Farah N et al. (2003) Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice. J Immunol 170:84-90

Tettelin, Herve; Masignani, Vega; Cieslewicz, Michael J et al. (2002) Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A 99:12391-6

Henneke, Philipp; Takeuchi, Osamu; Malley, Richard et al. (2002) Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol 169:3970-7

Brigtsen, Anne Karin; Kasper, Dennis L; Baker, Carol J et al. (2002) Induction of cross-reactive antibodies by immunization of healthy adults with types Ia and Ib group B streptococcal polysaccharide-tetanus toxoid conjugate vaccines. J Infect Dis 185:1277-84

Guttormsen, Hilde-Kari; Baker, Carol J; Nahm, Moon H et al. (2002) Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14. Infect Immun 70:1724-38

Henneke, P; Takeuchi, O; van Strijp, J A et al. (2001) Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol 167:7069-76

Zou, W; Li, J; Larocque, S et al. (2001) Construction of multivalent sialyl Le(x) from the type Ia group B Streptococcus capsular polysaccharide. Carbohydr Res 332:249-55