Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR008662-31
Application #
2078242
Study Section
Special Emphasis Panel (NSS)
Project Start
1974-09-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
31
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Dean, D D; Boyan, B D; Schwart, Z et al. (2001) Effect of 1alpha,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo. Endocrine 14:311-23
Bai, G; Howell, D S; Howard, G A et al. (2001) Basic calcium phosphate crystals up-regulate metalloproteinases but down-regulate tissue inhibitor of metalloproteinase-1 and -2 in human fibroblasts. Osteoarthritis Cartilage 9:416-22
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Sun, Y; Sun, Y; Wenger, L et al. (1999) p53 down-regulates human matrix metalloproteinase-1 (Collagenase-1) gene expression. J Biol Chem 274:11535-40
Grumbles, R M; Shao, L; Jeffrey, J J et al. (1997) Regulation of the rat interstitial collagenase promoter by IL-1 beta, c-Jun, and Ras-dependent signaling in growth plate chondrocytes. J Cell Biochem 67:92-102
Dean, D D; Schwartz, Z; Muniz, O E et al. (1997) Interleukin-1alpha and beta in growth plate cartilage are regulated by vitamin D metabolites in vivo. J Bone Miner Res 12:1560-9
Grumbles, R M; Shao, L; Jeffrey, J J et al. (1996) Regulation of rat interstitial collagenase gene expression in growth cartilage and chondrocytes by vitamin D3, interleukin-1 beta, and okadaic acid. J Cell Biochem 63:395-409
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Masse, P G; Rimnac, C M; Yamauchi, M et al. (1996) Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone 18:567-74
Dean, D D; Boyan, B D; Muniz, O E et al. (1996) Vitamin D metabolites regulate matrix vesicle metalloproteinase content in a cell maturation-dependent manner. Calcif Tissue Int 59:109-16

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