Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR011248-30
Application #
2078273
Study Section
Special Emphasis Panel (NSS)
Project Start
1975-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
30
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Rentz, Tyler J; Poobalarahi, Felicitta; Bornstein, Paul et al. (2007) SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem 282:22062-71
Rahkonen, Otto; Su, Ming; Hakovirta, Harri et al. (2004) Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ Res 94:83-90
Bornstein, Paul; Agah, Azin; Kyriakides, Themis R (2004) The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury. Int J Biochem Cell Biol 36:1115-25
Bornstein, Paul; Walsh, Vanessa; Tullis, Jennifer et al. (2002) The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. J Biol Chem 277:2605-13
Bornstein, Paul (2002) The NH(2)-terminal propeptides of fibrillar collagens: highly conserved domains with poorly understood functions. Matrix Biol 21:217-26
Hankenson, K D; Bain, S D; Kyriakides, T R et al. (2000) Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J Bone Miner Res 15:851-62
Hormuzdi, S G; Strandjord, T P; Madtes, D K et al. (1999) Mice with a targeted intronic deletion in the Col1a1 gene respond to bleomycin-induced pulmonary fibrosis with increased expression of the mutant allele. Matrix Biol 18:287-94
Liu, X; Wu, H; Loring, J et al. (1997) Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn 209:85-91
Bornstein, P (1996) Regulation of expression of the alpha 1 (I) collagen gene: a critical appraisal of the role of the first intron. Matrix Biol 15:3-10
Slack, J L; Parker, M I; Bornstein, P (1995) Transcriptional repression of the alpha 1(I) collagen gene by ras is mediated in part by an intronic AP1 site. J Cell Biochem 58:380-92

Showing the most recent 10 out of 17 publications