Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
7R37CA020260-21
Application #
2007221
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-03-01
Project End
1997-12-31
Budget Start
1996-11-15
Budget End
1996-12-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Schang, L M; Rosenberg, A; Schaffer, P A (1999) Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases. J Virol 73:2161-72
Jordan, R; Pepe, J; Schaffer, P A (1998) Characterization of a nerve growth factor-inducible cellular activity that enhances herpes simplex virus type 1 gene expression and replication of an ICP0 null mutant in cells of neural lineage. J Virol 72:5373-82
Lee, L Y; Schaffer, P A (1998) A virus with a mutation in the ICP4-binding site in the L/ST promoter of herpes simplex virus type 1, but not a virus with a mutation in open reading frame P, exhibits cell-type-specific expression of gamma(1)34.5 transcripts and latency-associated transc J Virol 72:4250-64
Schang, L M; Phillips, J; Schaffer, P A (1998) Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription. J Virol 72:5626-37
Jordan, R; Schaffer, P A (1997) Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis. J Virol 71:6850-62
Frazier, D P; Cox, D; Godshalk, E M et al. (1996) The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells. J Virol 70:7424-32
Wu, N; Watkins, S C; Schaffer, P A et al. (1996) Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J Virol 70:6358-69
Zhu, Z; DeLuca, N A; Schaffer, P A (1996) Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells. J Virol 70:5346-56
Frazier, D P; Cox, D; Godshalk, E M et al. (1996) Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells. J Virol 70:7433-44
Yao, F; Schaffer, P A (1995) An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1. J Virol 69:6249-58

Showing the most recent 10 out of 33 publications