Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA029243-16
Application #
2087890
Study Section
Virology Study Section (VR)
Project Start
1981-01-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Parsons, J Thomas; Slack-Davis, Jill; Tilghman, Robert et al. (2008) Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin Cancer Res 14:627-32
Iwanicki, Marcin P; Vomastek, Tomas; Tilghman, Robert W et al. (2008) FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci 121:895-905
Tilghman, Robert W; Parsons, J Thomas (2008) Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol 18:45-52
Owen, Katherine A; Pixley, Fiona J; Thomas, Keena S et al. (2007) Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol 179:1275-87
Vomastek, Tomas; Iwanicki, Marcin P; Schaeffer, Hans-Joerg et al. (2007) RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol 27:8296-305
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Liu, Yunhao; Yerushalmi, Gil M; Grigera, Pablo R et al. (2005) Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling. J Biol Chem 280:8884-92
Slack-Davis, Jill K; Eblen, Scott T; Zecevic, Maja et al. (2003) PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol 162:281-91
Kinley, Andrew W; Weed, Scott A; Weaver, Alissa M et al. (2003) Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol 13:384-93
Head, Julie A; Jiang, Dongyan; Li, Min et al. (2003) Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell 14:3216-29

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