Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA029323-16
Application #
2087913
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-02-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Pathology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Gordon, Gavin J; Butz, Genelle M; Grisham, Joe W et al. (2002) Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats. Transplantation 73:1236-43
Grisham, Joe W; Coleman, William B (2002) Molecular regulation of hepatocyte generation in adult animals. Am J Pathol 161:1107-10
Kaufmann, W K; Behe, C I; Golubovskaya, V M et al. (2001) Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells. Carcinogenesis 22:1257-69
Gordon, G J; Coleman, W B; Hixson, D C et al. (2000) Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am J Pathol 156:607-19
Gordon, G J; Coleman, W B; Grisham, J W (2000) Bax-mediated apoptosis in the livers of rats after partial hepatectomy in the retrorsine model of hepatocellular injury. Hepatology 32:312-20
Gordon, G J; Coleman, W B; Grisham, J W (2000) Induction of cytochrome P450 enzymes in the livers of rats treated with the pyrrolizidine alkaloid retrorsine. Exp Mol Pathol 69:17-26
Gordon, G J; Coleman, W B; Grisham, J W (2000) Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats. Am J Pathol 157:771-86
Coleman, W B; Ricketts, S L; Borchert, K M et al. (1999) Induction of rat WT1 gene expression correlates with human chromosome 11p11.2-p12-mediated suppression of tumorigenicity in rat liver epithelial tumor cell lines. Int J Oncol 14:957-63
McCullough, K D; Coleman, W B; Ricketts, S L et al. (1998) Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors. Proc Natl Acad Sci U S A 95:15333-8
McCullough, K D; Coleman, W B; Smith, G J et al. (1997) Age-dependent induction of hepatic tumor regression by the tissue microenvironment after transplantation of neoplastically transformed rat liver epithelial cells into the liver. Cancer Res 57:1807-13

Showing the most recent 10 out of 43 publications