Abstract

Monoclonal antibodies to hormone and factor receptors on human tumor cells will be used to inhibit the growth of these human tumors in athymic nude mice. The antibodies used will be those that have been found in vitro to act either as hormone agonists or antagonists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA042060-11
Application #
2090586
Study Section
Special Emphasis Panel (NSS)
Project Start
1985-07-05
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Liu, B; Fang, M; Schmidt, M et al. (2000) Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 82:1991-9
Milas, L; Mason, K; Hunter, N et al. (2000) In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 6:701-8
Chou, J L; Fan, Z; DeBlasio, T et al. (1999) Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor. Breast Cancer Res Treat 55:267-83
Ye, D; Mendelsohn, J; Fan, Z (1999) Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene 18:731-8
Ye, D; Mendelsohn, J; Fan, Z (1999) Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Clin Cancer Res 5:2171-7
Fan, Z; Shang, B Y; Lu, Y et al. (1997) Reciprocal changes in p27(Kip1) and p21(Cip1) in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors. Clin Cancer Res 3:1943-8
Baselga, J; Mendelsohn, J (1997) Type I receptor tyrosine kinases as targets for therapy in breast cancer. J Mammary Gland Biol Neoplasia 2:165-74
Baselga, J; Mendelsohn, J; Kim, Y M et al. (1996) Autocrine regulation of membrane transforming growth factor-alpha cleavage. J Biol Chem 271:3279-84
Wu, X; Rubin, M; Fan, Z et al. (1996) Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12:1397-403
Peng, D; Fan, Z; Lu, Y et al. (1996) Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 56:3666-9

Showing the most recent 10 out of 46 publications