Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA044550-10
Application #
2091516
Study Section
Special Emphasis Panel (NSS)
Project Start
1986-09-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1998-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
William Beaumont Hospital
Department
Type
DUNS #
City
Royal Oak
State
MI
Country
United States
Zip Code
48073
Lee, Y J; Chen, J C; Amoscato, A A et al. (2001) Protective role of Bcl2 in metabolic oxidative stress-induced cell death. J Cell Sci 114:677-84
Lee, Y J; Galoforo, S S; Battle, P et al. (2001) Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. Cancer Gene Ther 8:397-404
Lee, Y J; Galoforo, S S; Sim, J E et al. (2000) Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line. Free Radic Biol Med 28:575-84
Blackburn, R V; Spitz, D R; Liu, X et al. (1999) Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic Biol Med 26:419-30
Blackburn, R V; Galoforo, S S; Corry, P M et al. (1999) Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity. Int J Cancer 82:293-7
Lee, Y J; Corry, P M (1998) Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway. Role of Bcl-2 and c-Jun NH2-terminal kinase. J Biol Chem 273:29857-63
Blackburn, R V; Galoforo, S S; Corry, P M et al. (1998) Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells. Cancer Res 58:1358-62
Lee, Y J; Galoforo, S S; Berns, C M et al. (1998) Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. J Biol Chem 273:5294-9
Blackburn, R V; Galoforo, S S; Berns, C M et al. (1998) Differential induction of cell death in human glioma cell lines by sodium nitroprusside. Cancer 82:1137-45
Borrelli, M J; Stafford, D M; Rausch, C M et al. (1998) Diamide-induced cytotoxicity and thermotolerance in CHO cells. J Cell Physiol 177:483-92

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