Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK021085-19
Application #
2137548
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-09-01
Project End
1997-03-31
Budget Start
1995-09-01
Budget End
1997-03-31
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arizona
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Ying, Jinfa; Ahn, Jung-Mo; Jacobsen, Neil E et al. (2003) NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles. Biochemistry 42:2825-35
Ahn, J M; Gitu, P M; Medeiros, M et al. (2001) A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. J Med Chem 44:3109-16
Grieco, P; Gitu, P M; Hruby, V J (2001) Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis. J Pept Res 57:250-6
Ahn, J M; Medeiros, M; Trivedi, D et al. (2001) Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. J Pept Res 58:151-8
Ahn, J M; Medeiros, M; Trivedi, D et al. (2001) Development of potent truncated glucagon antagonists. J Med Chem 44:1372-9
Trivedi, D; Lin, Y; Ahn, J M et al. (2000) Design and synthesis of conformationally constrained glucagon analogues. J Med Chem 43:1714-22
Azizeh, B Y; Van Tine, B A; Trivedi, D et al. (1997) Pure glucagon antagonists: biological activities and cAMP accumulation using phosphodiesterase inhibitors. Peptides 18:633-41
Azizeh, B Y; Ahn, J M; Caspari, R et al. (1997) The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon. J Med Chem 40:2555-62
Van Tine, B A; Azizeh, B Y; Trivedi, D et al. (1996) Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinology 137:3316-22
Azizeh, B Y; Shenderovich, M D; Trivedi, D et al. (1996) Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem 39:2449-55

Showing the most recent 10 out of 22 publications