Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK029902-17
Application #
2138256
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1981-07-01
Project End
1997-06-30
Budget Start
1996-08-23
Budget End
1997-06-30
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Sperlazza, Justin; Rahmani, Mohamed; Beckta, Jason et al. (2015) Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood 126:1462-72
Rupon, Jeremy W; Wang, Shou Zhen; Gnanapragasam, Merlin et al. (2011) MBD2 contributes to developmental silencing of the human ?-globin gene. Blood Cells Mol Dis 46:212-9
Rupon, Jeremy W; Wang, Shou Zhen; Gaensler, Karin et al. (2006) Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A 103:6617-22
Kransdorf, Evan P; Wang, Shou Zhen; Zhu, Sheng Zu et al. (2006) MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood 108:2836-45
Singal, Rakesh; Wang, Shou Zhen; Sargent, Thanh et al. (2002) Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. J Biol Chem 277:1897-905
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Osborne, C S; Pasceri, P; Singal, R et al. (1999) Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells. J Virol 73:5490-6
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Olivieri, N F; Rees, D C; Ginder, G D et al. (1998) Elimination of transfusions through induction of fetal hemoglobin synthesis in Cooley's anemia. Ann N Y Acad Sci 850:100-9
Singal, R; Ferris, R; Little, J A et al. (1997) Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proc Natl Acad Sci U S A 94:13724-9

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