Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
7R37DK029902-19
Application #
2687570
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-07-01
Project End
2000-06-30
Budget Start
1997-08-16
Budget End
1998-06-30
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Sperlazza, Justin; Rahmani, Mohamed; Beckta, Jason et al. (2015) Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood 126:1462-72
Rupon, Jeremy W; Wang, Shou Zhen; Gnanapragasam, Merlin et al. (2011) MBD2 contributes to developmental silencing of the human ?-globin gene. Blood Cells Mol Dis 46:212-9
Rupon, Jeremy W; Wang, Shou Zhen; Gaensler, Karin et al. (2006) Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice. Proc Natl Acad Sci U S A 103:6617-22
Kransdorf, Evan P; Wang, Shou Zhen; Zhu, Sheng Zu et al. (2006) MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood 108:2836-45
Singal, Rakesh; Wang, Shou Zhen; Sargent, Thanh et al. (2002) Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. J Biol Chem 277:1897-905
Singal, R; Tu, Z J; Vanwert, J M et al. (2000) Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines. Anticancer Res 20:59-64
Osborne, C S; Pasceri, P; Singal, R et al. (1999) Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells. J Virol 73:5490-6
Singal, R; Ginder, G D (1999) DNA methylation. Blood 93:4059-70
Olivieri, N F; Rees, D C; Ginder, G D et al. (1998) Elimination of transfusions through induction of fetal hemoglobin synthesis in Cooley's anemia. Ann N Y Acad Sci 850:100-9
Singal, R; Ferris, R; Little, J A et al. (1997) Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proc Natl Acad Sci U S A 94:13724-9

Showing the most recent 10 out of 17 publications