This is a well-written application from an investigator with a long period of support. These investigations use human subjects and involve three experiments addressing four aims.
The first aim i s to assess the hypothesis that high energy intakes on high fat diets are due to the energy density of those foods rather than specifically relating to other properties of fat itself. In the second specific aim the hypothesis evaluated is that the weight of food acts through preabsorptive mechanisms while energy and nutrient content act through postabsorptive mechanisms. In the third specific aim the intent is to test the hypothesis that obese humans have an impaired ability to sense and respond to energy and fat content of foods within the short and long term periods. The fourth specific aim is to test whether it is true that foods of low energy intensity suppress initial hunger and prolong satiety more when they are matched to high density foods on a weight basis. The experiments testing these hypotheses involve two sets of short term feeding studies manipulating preloads, but significantly involving multiple sittings for the same individual subject. The third experiment is a long term comparison of diets of similar energy density but differing in fat content and then doing the reverse experiment of changing energy density while fixing fat content. The experiments carefully vary fat content while keeping the energy content constant or vice versa, all while maintaining constant palatability.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37DK039177-10
Application #
2620317
Study Section
Nutrition Study Section (NTN)
Project Start
1987-08-01
Project End
2002-09-29
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
10
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Rolls, Barbara J; Meengs, Jennifer S; Roe, Liane S (2014) Variations in cereal volume affect the amount selected and eaten for breakfast. J Acad Nutr Diet 114:1411-6
Hill, Brenna R; Rolls, Barbara J; Roe, Liane S et al. (2013) Ghrelin and peptide YY increase with weight loss during a 12-month intervention to reduce dietary energy density in obese women. Peptides 49:138-44
Williams, Rachel A; Roe, Liane S; Rolls, Barbara J (2013) Comparison of three methods to reduce energy density. Effects on daily energy intake. Appetite 66:75-83
Blatt, Alexandria D; Williams, Rachel A; Roe, Liane S et al. (2012) Effects of energy content and energy density of pre-portioned entrees on energy intake. Obesity (Silver Spring) 20:2010-8
Roe, Liane S; Meengs, Jennifer S; Rolls, Barbara J (2012) Salad and satiety. The effect of timing of salad consumption on meal energy intake. Appetite 58:242-8
Blatt, Alexandria D; Roe, Liane S; Rolls, Barbara J (2011) Hidden vegetables: an effective strategy to reduce energy intake and increase vegetable intake in adults. Am J Clin Nutr 93:756-63
Blatt, Alexandria D; Roe, Liane S; Rolls, Barbara J (2011) Increasing the protein content of meals and its effect on daily energy intake. J Am Diet Assoc 111:290-4
Obbagy, Julie E; Condrasky, Margaret D; Roe, Liane S et al. (2011) Chefs' opinions about reducing the calorie content of menu items in restaurants. Obesity (Silver Spring) 19:332-7
Rolls, Barbara J (2010) Plenary Lecture 1: Dietary strategies for the prevention and treatment of obesity. Proc Nutr Soc 69:70-9
Flood-Obbagy, Julie E; Rolls, Barbara J (2009) The effect of fruit in different forms on energy intake and satiety at a meal. Appetite 52:416-22

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