Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37EY001844-20
Application #
2158240
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-07-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Wang, Tian; Reingruber, Jürgen; Woodruff, Michael L et al. (2018) The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx. J Biol Chem 293:15332-15346
Chen, Ching-Kang; Woodruff, Michael L; Fain, Gordon L (2015) Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation. J Gen Physiol 145:213-24
Reingruber, Jürgen; Holcman, David; Fain, Gordon L (2015) How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception. Bioessays 37:1243-52
Morshedian, Ala; Fain, Gordon L (2015) Single-photon sensitivity of lamprey rods with cone-like outer segments. Curr Biol 25:484-7
Woodruff, Michael L; Rajala, Ammaji; Fain, Gordon L et al. (2015) Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep 5:7858
Woodruff, Michael L; Rajala, Ammaji; Fain, Gordon L et al. (2014) Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem 289:358-64
Reingruber, Jürgen; Pahlberg, Johan; Woodruff, Michael L et al. (2013) Detection of single photons by toad and mouse rods. Proc Natl Acad Sci U S A 110:19378-83
Chen, Ching-Kang; Woodruff, Michael L; Chen, Frank S et al. (2012) Modulation of mouse rod response decay by rhodopsin kinase and recoverin. J Neurosci 32:15998-6006
Tsang, Stephen H; Woodruff, Michael L; Lin, Chyuan-Sheng et al. (2012) Effect of the ILE86TER mutation in the ? subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Cell Signal 24:181-8
Nymark, S; Frederiksen, R; Woodruff, M L et al. (2012) Bleaching of mouse rods: microspectrophotometry and suction-electrode recording. J Physiol 590:2353-64

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