Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37EY003897-20
Application #
6178435
Study Section
Special Emphasis Panel (NSS)
Program Officer
Liberman, Ellen S
Project Start
1981-08-01
Project End
2004-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
20
Fiscal Year
2000
Total Cost
$426,030
Indirect Cost
Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Wu, Mingxing; Zhang, Xinyu; Bian, Qingning et al. (2012) Oligomerization with wt ýýA- and ýýB-crystallins reduces proteasome-mediated degradation of C-terminally truncated ýýA-crystallin. Invest Ophthalmol Vis Sci 53:2541-50
Laganowsky, Arthur; Benesch, Justin L P; Landau, Meytal et al. (2010) Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci 19:1031-43
Huang, Qingling; Ding, Linlin; Phan, Kim B et al. (2009) Mechanism of cataract formation in alphaA-crystallin Y118D mutation. Invest Ophthalmol Vis Sci 50:2919-26
Chen, Ling; Holland, Gary N; Yu, Fei et al. (2008) Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis. Invest Ophthalmol Vis Sci 49:4476-81
Wang, Kaijun; Cheng, Catherine; Li, Lin et al. (2007) GammaD-crystallin associated protein aggregation and lens fiber cell denucleation. Invest Ophthalmol Vis Sci 48:3719-28
Ecroyd, Heath; Meehan, Sarah; Horwitz, Joseph et al. (2007) Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity. Biochem J 401:129-41
Xia, Chun-hong; Liu, Haiquan; Chang, Bo et al. (2006) Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest Ophthalmol Vis Sci 47:3004-10
Xia, Chun-hong; Cheng, Catherine; Huang, Qingling et al. (2006) Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp Eye Res 83:688-96
Cohen, Jonathan H; Piatigorsky, Joram; Ding, Linlin et al. (2005) Vertebrate-like betagamma-crystallins in the ocular lenses of a copepod. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:291-8
Liu, Haiquan; Du, Xin; Wang, Meng et al. (2005) Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. J Biol Chem 280:25071-8

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