Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37EY003897-23
Application #
6642793
Study Section
Special Emphasis Panel (NSS)
Program Officer
Liberman, Ellen S
Project Start
1981-08-01
Project End
2004-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
23
Fiscal Year
2003
Total Cost
$462,239
Indirect Cost
Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Wu, Mingxing; Zhang, Xinyu; Bian, Qingning et al. (2012) Oligomerization with wt ýýA- and ýýB-crystallins reduces proteasome-mediated degradation of C-terminally truncated ýýA-crystallin. Invest Ophthalmol Vis Sci 53:2541-50
Laganowsky, Arthur; Benesch, Justin L P; Landau, Meytal et al. (2010) Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci 19:1031-43
Huang, Qingling; Ding, Linlin; Phan, Kim B et al. (2009) Mechanism of cataract formation in alphaA-crystallin Y118D mutation. Invest Ophthalmol Vis Sci 50:2919-26
Chen, Ling; Holland, Gary N; Yu, Fei et al. (2008) Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis. Invest Ophthalmol Vis Sci 49:4476-81
Wang, Kaijun; Cheng, Catherine; Li, Lin et al. (2007) GammaD-crystallin associated protein aggregation and lens fiber cell denucleation. Invest Ophthalmol Vis Sci 48:3719-28
Ecroyd, Heath; Meehan, Sarah; Horwitz, Joseph et al. (2007) Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity. Biochem J 401:129-41
Xia, Chun-hong; Liu, Haiquan; Chang, Bo et al. (2006) Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest Ophthalmol Vis Sci 47:3004-10
Xia, Chun-hong; Cheng, Catherine; Huang, Qingling et al. (2006) Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp Eye Res 83:688-96
Aquilina, J Andrew; Benesch, Justin L P; Ding, Lin Lin et al. (2005) Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation. J Biol Chem 280:14485-91
Treweek, Teresa M; Rekas, Agata; Lindner, Robyn A et al. (2005) R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable. FEBS J 272:711-24

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