Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM018938-25
Application #
2173401
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
25
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Reinhardt, Laurie A; Thoden, James B; Peters, Greg S et al. (2013) pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis). FEBS Lett 587:2876-81
Smith, Brian C; Anderson, Mark A; Hoadley, Kelly A et al. (2012) Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae. Biochemistry 51:243-56
Thoden, James B; Reinhardt, Laurie A; Cook, Paul D et al. (2012) Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses. Biochemistry 51:3433-44
Saylor, Benjamin T; Reinhardt, Laurie A; Lu, Zhibing et al. (2012) A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase. Biochemistry 51:2911-20
Marlier, John F; Robins, Lori I; Tucker, Kathryn A et al. (2010) A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea. Biochemistry 49:8213-9
Van Vleet, Jeremy; Kleeb, Andreas; Kast, Peter et al. (2010) 13C isotope effect on the reaction catalyzed by prephenate dehydratase. Biochim Biophys Acta 1804:752-4
Pinto-Tomas, Adrian A; Anderson, Mark A; Suen, Garret et al. (2009) Symbiotic nitrogen fixation in the fungus gardens of leaf-cutter ants. Science 326:1120-3
Van Vleet, Jeremy L; Reinhardt, Laurie A; Miller, Brian G et al. (2008) Carbon isotope effect study on orotidine 5'-monophosphate decarboxylase: support for an anionic intermediate. Biochemistry 47:798-803
Poyner, Russell R; Anderson, Mark A; Bandarian, Vahe et al. (2006) Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase. J Am Chem Soc 128:7120-1
Waldrop, G L; Braxton, B F; Urbauer, J L et al. (1994) Secondary 18O and primary 13C isotope effects as a probe of transition-state structure for enzymatic decarboxylation of oxalacetate. Biochemistry 33:5262-7

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