Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM021941-30
Application #
6615963
Study Section
Special Emphasis Panel (NSS)
Program Officer
Tompkins, Laurie
Project Start
1978-02-01
Project End
2009-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
30
Fiscal Year
2004
Total Cost
$616,369
Indirect Cost
Name
Cornell University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Strobel, Eric J; Roberts, Jeffrey W (2015) Two transcription pause elements underlie a ?70-dependent pause cycle. Proc Natl Acad Sci U S A 112:E4374-80
Strobel, Eric J; Roberts, Jeffrey W (2014) Regulation of promoter-proximal transcription elongation: enhanced DNA scrunching drives ?Q antiterminator-dependent escape from a ?70-dependent pause. Nucleic Acids Res 42:5097-108
Liu, Xiaoqiu; Jiang, Huifeng; Gu, Zhenglong et al. (2013) High-resolution view of bacteriophage lambda gene expression by ribosome profiling. Proc Natl Acad Sci U S A 110:11928-33
Perdue, Sarah A; Roberts, Jeffrey W (2010) A backtrack-inducing sequence is an essential component of Escherichia coli ?(70)-dependent promoter-proximal pausing. Mol Microbiol 78:636-50
Shankar, Smita; Hatoum, Asma; Roberts, Jeffrey W (2007) A transcription antiterminator constructs a NusA-dependent shield to the emerging transcript. Mol Cell 27:914-27
Park, Joo-Seop; Roberts, Jeffrey W (2006) Role of DNA bubble rewinding in enzymatic transcription termination. Proc Natl Acad Sci U S A 103:4870-5
Nickels, Bryce E; Roberts, Christine W; Roberts, Jeffrey W et al. (2006) RNA-mediated destabilization of the sigma(70) region 4/beta flap interaction facilitates engagement of RNA polymerase by the Q antiterminator. Mol Cell 24:457-68
Holmes, Shannon F; Santangelo, Thomas J; Cunningham, Candice K et al. (2006) Kinetic investigation of Escherichia coli RNA polymerase mutants that influence nucleotide discrimination and transcription fidelity. J Biol Chem 281:18677-83
Wickstrum, Jason R; Santangelo, Thomas J; Egan, Susan M (2005) Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli. J Bacteriol 187:6708-18
Guo, Jingshu; Roberts, Jeffrey W (2004) DNA binding regions of Q proteins of phages lambda and phi80. J Bacteriol 186:3599-608

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