Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM025765-19
Application #
2174527
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Horitani, Masaki; Offenbacher, Adam R; Carr, Cody A Marcus et al. (2017) 13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling. J Am Chem Soc 139:1984-1997
Collazo, Lara; Klinman, Judith P (2016) Control of the Position of Oxygen Delivery in Soybean Lipoxygenase-1 by Amino Acid Side Chains within a Gas Migration Channel. J Biol Chem 291:9052-9
Zhang, Jianyu; Klinman, Judith P (2016) Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase. J Am Chem Soc 138:9158-65
Hu, Shenshen; Cattin-Ortolá, Jérôme; Munos, Jeffrey W et al. (2016) Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C-H Activation by Soybean Lipoxygenase-1. Angew Chem Int Ed Engl 55:9361-4
Zhang, Jianyu; Kulik, Heather J; Martinez, Todd J et al. (2015) Mediation of donor-acceptor distance in an enzymatic methyl transfer reaction. Proc Natl Acad Sci U S A 112:7954-9
Zhang, Jianyu; Klinman, Judith P (2015) High-performance liquid chromatography separation of the (S,S)- and (R,S)-forms of S-adenosyl-L-methionine. Anal Biochem 476:81-3
Zhu, Hui; Peck, Spencer C; Bonnot, Florence et al. (2015) Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species. J Am Chem Soc 137:10448-51
Sharma, Sudhir C; Klinman, Judith P (2015) Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase. Biochemistry 54:5447-56
Zhu, Hui; Sommerhalter, Monika; Nguy, Andy K L et al. (2015) Solvent and Temperature Probes of the Long-Range Electron-Transfer Step in Tyramine ?-Monooxygenase: Demonstration of a Long-Range Proton-Coupled Electron-Transfer Mechanism. J Am Chem Soc 137:5720-9
Klinman, Judith P (2015) Dynamically achieved active site precision in enzyme catalysis. Acc Chem Res 48:449-56

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