Mechanisms of Yeast Transcriptional Inititation

Struhl, Kevin

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37GM030186-15
• Application #: 2175719
• Study Section: Molecular Cytology Study Section (CTY)
• Project Start: 1982-03-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 15
• Fiscal Year: 1996

Institution

• Name: Harvard University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 082359691
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Moqtaderi, Zarmik; Geisberg, Joseph V; Struhl, Kevin (2018) Extensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability. Mol Cell 72:849-861.e6

Petrenko, Natalia; Jin, Yi; Wong, Koon Ho et al. (2017) Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo. Elife 6:

Petrenko, Natalia; Jin, Yi; Wong, Koon Ho et al. (2016) Mediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell 64:443-454

Miotto, Benoit; Ji, Zhe; Struhl, Kevin (2016) Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers. Proc Natl Acad Sci U S A 113:E4810-9

Jin, Yi; Geisberg, Joseph V; Moqtaderi, Zarmik et al. (2015) Mapping 3' mRNA isoforms on a genomic scale. Curr Protoc Mol Biol 110:4.23.1-17

Wong, Koon Ho; Jin, Yi; Struhl, Kevin (2014) TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape. Mol Cell 54:601-12

Moqtaderi, Zarmik; Geisberg, Joseph V; Struhl, Kevin (2014) Secondary structures involving the poly(A) tail and other 3' sequences are major determinants of mRNA isoform stability in yeast. Microb Cell 1:137-139

Geisberg, Joseph V; Moqtaderi, Zarmik; Fan, Xiaochun et al. (2014) Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell 156:812-24

Moqtaderi, Zarmik; Geisberg, Joseph V; Jin, Yi et al. (2013) Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts. Proc Natl Acad Sci U S A 110:11073-8

Struhl, Kevin; Segal, Eran (2013) Determinants of nucleosome positioning. Nat Struct Mol Biol 20:267-73