Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM036452-15
Application #
2839795
Study Section
Special Emphasis Panel (NSS)
Program Officer
Lewis, Catherine D
Project Start
1990-09-01
Project End
2004-11-30
Budget Start
1999-12-10
Budget End
2000-11-30
Support Year
15
Fiscal Year
2000
Total Cost
$373,714
Indirect Cost
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Yang, Xiaojing; Stojkovi?, Emina A; Ozarowski, Wesley B et al. (2015) Light Signaling Mechanism of Two Tandem Bacteriophytochromes. Structure 23:1179-89
Moffat, Keith (2014) Time-resolved crystallography and protein design: signalling photoreceptors and optogenetics. Philos Trans R Soc Lond B Biol Sci 369:20130568
Stojkovi?, Emina A; Toh, K C; Alexandre, Maxime T A et al. (2014) FTIR Spectroscopy Revealing Light-Dependent Refolding of the Conserved Tongue Region of Bacteriophytochrome. J Phys Chem Lett 5:2512-2515
Jung, Yang Ouk; Lee, Jae Hyuk; Kim, Joonghan et al. (2013) Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography. Nat Chem 5:212-20
Nieder, Jana B; Stojkovi?, Emina A; Moffat, Keith et al. (2013) Pigment-protein interactions in phytochromes probed by fluorescence line narrowing spectroscopy. J Phys Chem B 117:14940-50
Halavaty, Andrei S; Moffat, Keith (2013) Coiled-coil dimerization of the LOV2 domain of the blue-light photoreceptor phototropin 1 from Arabidopsis thaliana. Acta Crystallogr Sect F Struct Biol Cryst Commun 69:1316-21
Sugishima, Masakazu; Moffat, Keith; Noguchi, Masato (2012) Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry 51:8554-62
Ohlendorf, Robert; Vidavski, Roee R; Eldar, Avigdor et al. (2012) From dusk till dawn: one-plasmid systems for light-regulated gene expression. J Mol Biol 416:534-42
Mitra, Devrani; Yang, Xiaojing; Moffat, Keith (2012) Crystal structures of Aureochrome1 LOV suggest new design strategies for optogenetics. Structure 20:698-706
Kostov, Konstantin S; Moffat, Keith (2011) Cluster analysis of time-dependent crystallographic data: Direct identification of time-independent structural intermediates. Biophys J 100:440-9

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