Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM038149-20
Application #
6921896
Study Section
Special Emphasis Panel (NSS)
Program Officer
Okita, Richard T
Project Start
1986-08-01
Project End
2008-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
20
Fiscal Year
2005
Total Cost
$507,465
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Bushel, P R; Fannin, R D; Gerrish, K et al. (2017) Blood gene expression profiling of an early acetaminophen response. Pharmacogenomics J 17:230-236
Fannin, R D; Gerrish, K; Sieber, S O et al. (2016) Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther 99:432-41
Jeffries, Rex E; Gamcsik, Michael P; Keshari, Kayvan R et al. (2013) Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ³¹P and ¹³C NMR spectroscopy. Tissue Eng Part C Methods 19:93-100
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Fannin, Rick D; Russo, Mark; O'Connell, Thomas M et al. (2010) Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. Hepatology 51:227-36
Harrill, Alison H; Watkins, Paul B; Su, Stephen et al. (2009) Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res 19:1507-15
Leslie, Elaine M; Watkins, Paul B; Kim, Richard B et al. (2007) Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. J Pharmacol Exp Ther 321:1170-8
Lamba, Jatinder K; Chen, Xin; Lan, Lu-Bin et al. (2006) Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans. Pharmacogenet Genomics 16:415-27
Paine, Mary F; Widmer, Wilbur W; Hart, Heather L et al. (2006) A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction. Am J Clin Nutr 83:1097-105
Paine, Mary F; Hart, Heather L; Ludington, Shana S et al. (2006) The human intestinal cytochrome P450 ""pie"". Drug Metab Dispos 34:880-6

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