Glycoconjugates in Development And Immunity

Hart, Gerald Warren

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 4R37HD013563-26
• Application #: 6551320
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Lock, Allan
• Project Start: 1998-04-01
• Project End: 2008-03-31
• Budget Start: 2003-04-01
• Budget End: 2004-03-31
• Support Year: 26
• Fiscal Year: 2003
• Total Cost: $460,427

Institution

• Name: Johns Hopkins University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 001910777
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Hart, Gerald W; Slawson, Chad; Ramirez-Correa, Genaro et al. (2011) Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem 80:825-58

Zachara, Natasha E; Molina, Henrik; Wong, Ker Yi et al. (2011) The dynamic stress-induced ""O-GlcNAc-ome"" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways. Amino Acids 40:793-808

Slawson, Chad; Hart, Gerald W (2011) O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer 11:678-84

Butkinaree, Chutikarn; Park, Kyoungsook; Hart, Gerald W (2010) O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta 1800:96-106

Li, Xi; Molina, Henrik; Huang, Haiyan et al. (2009) O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation. J Biol Chem 284:19248-54

Housley, Michael P; Udeshi, Namrata D; Rodgers, Joseph T et al. (2009) A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem 284:5148-57

Zachara, Natasha E (2009) Detecting the ""O-GlcNAc-ome""; detection, purification, and analysis of O-GlcNAc modified proteins. Methods Mol Biol 534:251-79

Copeland, Ronald J; Bullen, John W; Hart, Gerald W (2008) Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab 295:E17-28

Cheung, Win D; Hart, Gerald W (2008) AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem 283:13009-20

Slawson, Chad; Lakshmanan, T; Knapp, Spencer et al. (2008) A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell 19:4130-40