Project Start
1985-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Kochhar, D M; Jiang, H; Penner, J D et al. (1998) The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. Int J Dev Biol 42:601-8
Kochhar, D M; Jiang, H; Penner, J D et al. (1996) Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid. Chem Biol Interact 100:1-12
Jiang, H; Penner, J D; Beard, R L et al. (1995) Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids. Biochem Pharmacol 50:669-76
Kochhar, D M; Jiang, H; Penner, J D et al. (1995) Placental transfer and developmental effects of 9-cis retinoic acid in mice. Teratology 51:257-65
Jiang, H; Soprano, D R; Li, S W et al. (1995) Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors. Int J Dev Biol 39:617-27
Jiang, H; Gyda 3rd, M; Harnish, D C et al. (1994) Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor-beta 2 mRNA levels in treated embryos. Teratology 50:38-43
Soprano, D R; Gyda 3rd, M; Jiang, H et al. (1994) A sustained elevation in retinoic acid receptor-beta 2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis. Mech Dev 45:243-53
Soprano, D R; Harnish, D C; Soprano, K J et al. (1993) Correlations of RAR isoforms and cellular retinoid-binding proteins mRNA levels with retinoid-induced teratogenesis. J Nutr 123:367-71
Kochhar, D M; Jiang, H; Harnish, D C et al. (1993) Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated. Prog Clin Biol Res 383B:815-25
Soprano, D R; Tairis, N; Gyda 3rd, M et al. (1993) Induction of RAR-beta 2 gene expression in embryos and RAR-beta 2 transactivation by the synthetic retinoid Ro 13-6307 correlates with its high teratogenic potency. Toxicol Appl Pharmacol 122:159-63

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