Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL022273-11
Application #
3485771
Study Section
Toxicology Study Section (TOX)
Project Start
1978-04-01
Project End
1993-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Type
Schools of Pharmacy
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Fung, Ho-Leung (2004) Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved? Annu Rev Pharmacol Toxicol 44:67-85
Wang, Ellen Q; Balthasar, Joseph P; Fung, Ho-Leung (2004) Pharmacodynamics of in vivo nitroglycerin tolerance in normal conscious rats: effects of dose and dosing protocol. Pharm Res 21:114-20
Khanna, Ashish; Rossman, Jon; Caty, Michael G et al. (2003) Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. J Surg Res 114:15-24
Lee, Woo In; Fung, Ho Leung (2003) Mechanism-based partial inactivation of glutathione S-transferases by nitroglycerin: tyrosine nitration vs sulfhydryl oxidation. Nitric Oxide 8:103-10
Lee, Woo-In; Xu, Ye; Fung, Sun-Mi et al. (2003) eNOS-dependent vascular interaction between nitric oxide and calcitonin gene-related peptide in mice: gender selectivity and effects on blood aggregation. Regul Pept 110:115-22
Wang, Ellen Q; Lee, Woo-In; Brazeau, Daniel et al. (2002) cDNA microarray analysis of vascular gene expression after nitric oxide donor infusions in rats: implications for nitrate tolerance mechanisms. AAPS PharmSci 4:E10
Wang, Ellen Q; Fung, Ho-Leung (2002) Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats. AAPS PharmSci 4:E28
Kielbasa, W; Fung, H L (2000) Pharmacokinetics of a model organic nitrite inhalant and its alcohol metabolite in rats. Drug Metab Dispos 28:386-91
Booth, B P; Tabrizi-Fard, M A; Fung, H (2000) Calcitonin gene-related peptide-dependent vascular relaxation of rat aorta. An additional mechanism for nitroglycerin. Biochem Pharmacol 59:1603-9
Maurer, T; Fung, H L (2000) Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: application to nitric oxide synthase. AAPS PharmSci 2:E8

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