Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL022273-19
Application #
2215558
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-04-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Fung, Ho-Leung (2004) Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved? Annu Rev Pharmacol Toxicol 44:67-85
Wang, Ellen Q; Balthasar, Joseph P; Fung, Ho-Leung (2004) Pharmacodynamics of in vivo nitroglycerin tolerance in normal conscious rats: effects of dose and dosing protocol. Pharm Res 21:114-20
Khanna, Ashish; Rossman, Jon; Caty, Michael G et al. (2003) Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. J Surg Res 114:15-24
Lee, Woo In; Fung, Ho Leung (2003) Mechanism-based partial inactivation of glutathione S-transferases by nitroglycerin: tyrosine nitration vs sulfhydryl oxidation. Nitric Oxide 8:103-10
Lee, Woo-In; Xu, Ye; Fung, Sun-Mi et al. (2003) eNOS-dependent vascular interaction between nitric oxide and calcitonin gene-related peptide in mice: gender selectivity and effects on blood aggregation. Regul Pept 110:115-22
Wang, Ellen Q; Lee, Woo-In; Brazeau, Daniel et al. (2002) cDNA microarray analysis of vascular gene expression after nitric oxide donor infusions in rats: implications for nitrate tolerance mechanisms. AAPS PharmSci 4:E10
Wang, Ellen Q; Fung, Ho-Leung (2002) Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats. AAPS PharmSci 4:E28
Maurer, T S; Pan, J; Booth, B P et al. (2000) Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation. Bioorg Med Chem Lett 10:1077-80
Maurer, T S; Tabrizi-Fard, M A; Fung, H L (2000) Impact of mechanism-based enzyme inactivation on inhibitor potency: implications for rational drug discovery. J Pharm Sci 89:1404-14
Kielbasa, W; Fung, H L (2000) Pharmacokinetics of a model organic nitrite inhalant and its alcohol metabolite in rats. Drug Metab Dispos 28:386-91

Showing the most recent 10 out of 76 publications