Prostaglandins - the Kidney and Hypertension

Dunn, Michael J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 2R37HL022563-13
• Application #: 3485787
• Study Section: Experimental Cardiovascular Sciences Study Section (ECS)
• Project Start: 1977-09-01
• Project End: 1994-08-31
• Budget Start: 1989-09-01
• Budget End: 1990-08-31
• Support Year: 13
• Fiscal Year: 1989

Institution

• Name: Case Western Reserve University
• Type: Schools of Medicine
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Rufanova, Victoriya A; Alexanian, Anna; Ostendorf, Tammo et al. (2010) Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can J Physiol Pharmacol 88:808-16

Chahdi, Ahmed; Sorokin, Andrey (2010) The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun 391:1330-5

Pavlov, Tengis S; Chahdi, Ahmed; Ilatovskaya, Daria V et al. (2010) Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol 21:833-43

Chahdi, Ahmed; Sorokin, Andrey (2010) Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. Cell Signal 22:325-9

Rufanova, Victoriya A; Alexanian, Anna; Wakatsuki, Tetsuro et al. (2009) Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. J Cell Physiol 219:45-56

Rufanova, Victoriya A; Lianos, Elias; Alexanian, Anna et al. (2009) C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Kidney Int 75:31-40

Chahdi, Ahmed; Sorokin, Andrey (2008) Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell 19:2609-19

Chahdi, Ahmed; Sorokin, Andrey (2008) Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol 28:1679-87

Sarkozi, Rita; Miller, Bradley; Pollack, Verena et al. (2007) ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. J Cell Physiol 211:88-100

Rufanova, Victoriya A; Sorokin, Andrey (2006) CrkII associates with BCAR3 in response to endothelin-1 in human glomerular mesangial cells. Exp Biol Med (Maywood) 231:752-6