Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL022563-20
Application #
2028036
Study Section
Special Emphasis Panel (NSS)
Project Start
1995-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Rufanova, Victoriya A; Alexanian, Anna; Ostendorf, Tammo et al. (2010) Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can J Physiol Pharmacol 88:808-16
Chahdi, Ahmed; Sorokin, Andrey (2010) The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun 391:1330-5
Pavlov, Tengis S; Chahdi, Ahmed; Ilatovskaya, Daria V et al. (2010) Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol 21:833-43
Chahdi, Ahmed; Sorokin, Andrey (2010) Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. Cell Signal 22:325-9
Rufanova, Victoriya A; Alexanian, Anna; Wakatsuki, Tetsuro et al. (2009) Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. J Cell Physiol 219:45-56
Rufanova, Victoriya A; Lianos, Elias; Alexanian, Anna et al. (2009) C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Kidney Int 75:31-40
Chahdi, Ahmed; Sorokin, Andrey (2008) Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell 19:2609-19
Chahdi, Ahmed; Sorokin, Andrey (2008) Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol 28:1679-87
Sarkozi, Rita; Miller, Bradley; Pollack, Verena et al. (2007) ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. J Cell Physiol 211:88-100
Rufanova, Victoriya A; Sorokin, Andrey (2006) CrkII associates with BCAR3 in response to endothelin-1 in human glomerular mesangial cells. Exp Biol Med (Maywood) 231:752-6

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