Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL030050-15
Application #
2216560
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-06-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Kranendonk, Michel; Marohnic, Christopher C; Panda, Satya P et al. (2008) Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. Arch Biochem Biophys 475:93-9
Erdal, Erik P; Martasek, Pavel; Roman, Linda J et al. (2007) Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem 15:6096-108
Seo, Jiwon; Martasek, Pavel; Roman, Linda J et al. (2007) Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. Bioorg Med Chem 15:1928-38
Gao, Ying Tong; Roman, Linda J; Martasek, Pavel et al. (2007) Oxygen metabolism by endothelial nitric-oxide synthase. J Biol Chem 282:28557-65
Gao, Ying Tong; Panda, Satya Prakash; Roman, Linda J et al. (2007) Oxygen metabolism by neuronal nitric-oxide synthase. J Biol Chem 282:7921-9
Litzinger, Elizabeth A; Martasek, Pavel; Roman, Linda J et al. (2006) Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. Bioorg Med Chem 14:3185-98
Sue Masters, Bettie; Marohnic, Christopher C (2006) Cytochromes P450--a family of proteins and scientists-understanding their relationships. Drug Metab Rev 38:209-25
Panda, Satya Prakash; Gao, Ying Tong; Roman, Linda J et al. (2006) The role of a conserved serine residue within hydrogen bonding distance of FAD in redox properties and the modulation of catalysis by Ca2+/calmodulin of constitutive nitric-oxide synthases. J Biol Chem 281:34246-57
Mbadugha, Bessie N A; Seo, Jiwon; Ji, Haitao et al. (2006) Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem 14:3681-90
Marohnic, Christopher C; Panda, Satya P; Martasek, Pavel et al. (2006) Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase. J Biol Chem 281:35975-82

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