Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL030050-08
Application #
3485978
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1982-06-01
Project End
1990-06-30
Budget Start
1990-04-01
Budget End
1990-06-30
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Kranendonk, Michel; Marohnic, Christopher C; Panda, Satya P et al. (2008) Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. Arch Biochem Biophys 475:93-9
Erdal, Erik P; Martasek, Pavel; Roman, Linda J et al. (2007) Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem 15:6096-108
Seo, Jiwon; Martasek, Pavel; Roman, Linda J et al. (2007) Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. Bioorg Med Chem 15:1928-38
Gao, Ying Tong; Roman, Linda J; Martasek, Pavel et al. (2007) Oxygen metabolism by endothelial nitric-oxide synthase. J Biol Chem 282:28557-65
Gao, Ying Tong; Panda, Satya Prakash; Roman, Linda J et al. (2007) Oxygen metabolism by neuronal nitric-oxide synthase. J Biol Chem 282:7921-9
Panda, Satya Prakash; Gao, Ying Tong; Roman, Linda J et al. (2006) The role of a conserved serine residue within hydrogen bonding distance of FAD in redox properties and the modulation of catalysis by Ca2+/calmodulin of constitutive nitric-oxide synthases. J Biol Chem 281:34246-57
Mbadugha, Bessie N A; Seo, Jiwon; Ji, Haitao et al. (2006) Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem 14:3681-90
Marohnic, Christopher C; Panda, Satya P; Martasek, Pavel et al. (2006) Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase. J Biol Chem 281:35975-82
Whitsett, Jennifer; Martasek, Pavel; Zhao, Hongtao et al. (2006) Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic Biol Med 40:2056-68
Ji, Haitao; Gomez-Vidal, Jose A; Martasek, Pavel et al. (2006) Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. J Med Chem 49:6254-63

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