The long-term goal of this project is to improve understanding of how the nervous system selects and executes individuated finger movements. Individuated movements are the first lost and last recovered when neurologic lesions affect the motor cortex or corticospinal tract. The resulting motor deficits impair use of the hand and fingers in everyday tasks. The present application proposes to examine the role of synchrony among primary motor cortex neurons in the learning and performance of skilled finger movements. Studies will focus on changes in synchrony in three, inter-related situations: 1) changes that relate to long-term training at a repertoire of skilled finger movements, 2) changes that depend on which particular movements are performed, and 3) changes that occur when a skilled subject attempts a novel movement. Such changes in synchrony could enable the nervous system to more efficiently activate the varied combinations of muscles needed for execution of skilled movements. Multiple neuron recording and spike-triggered averaging of electromyographic activity will be used together to examine synchrony both between pairs of motor cortex neurons, and among larger ensembles of neurons that provide inputs to spinal motoneuron pools. The proposed studies will address the following specific questions: 1) What is the time course of the increase in synchrony over long-term training? 2) Does synchrony occur during only a subset of finger movements or task time periods? 3) Do patterns of synchrony change when a fully trained subject practices a novel movement? 4) Does synchrony occur predominantly in corticospinal or non-corticospinal primary motor cortex neurons?
| Perel, Sagi; Schwartz, Andrew B; Ventura, Valérie (2014) Automatic scan test for detection of functional connectivity between cortex and muscles. J Neurophysiol 112:490-9 |
| Perel, Sagi; Schwartz, Andrew B; Ventura, Valérie (2014) Single-snippet analysis for detection of postspike effects. Neural Comput 26:40-56 |
| Law, Andrew J; Sharma, Gaurav; Schieber, Marc H (2010) An information transmission measure for the analysis of effective connectivity among cortical neurons. Conf Proc IEEE Eng Med Biol Soc 2010:3293-6 |
| Aggarwal, Vikram; Tenore, Francesco; Acharya, Soumyadipta et al. (2009) Cortical decoding of individual finger and wrist kinematics for an upper-limb neuroprosthesis. Conf Proc IEEE Eng Med Biol Soc 2009:4535-8 |
| Schieber, Marc H; Lang, C E; Reilly, K T et al. (2009) Selective activation of human finger muscles after stroke or amputation. Adv Exp Med Biol 629:559-75 |
| Acharya, Soumyadipta; Tenore, Francesco; Aggarwal, Vikram et al. (2008) Decoding individuated finger movements using volume-constrained neuronal ensembles in the M1 hand area. IEEE Trans Neural Syst Rehabil Eng 16:15-23 |
| Reilly, Karen T; Schieber, Marc H; McNulty, Penelope A (2008) Selectivity of voluntary finger flexion during ischemic nerve block of the hand. Exp Brain Res 188:385-97 |
| Mollazadeh, Mohsen; Aggarwal, Vikram; Singhal, Girish et al. (2008) Spectral modulation of LFP activity in M1 during dexterous finger movements. Conf Proc IEEE Eng Med Biol Soc 2008:5314-7 |
| Aggarwal, Vikram; Acharya, Soumyadipta; Tenore, Francesco et al. (2008) Asynchronous decoding of dexterous finger movements using M1 neurons. IEEE Trans Neural Syst Rehabil Eng 16:3-14 |
| Hamed, S Ben; Schieber, M H; Pouget, A (2007) Decoding M1 neurons during multiple finger movements. J Neurophysiol 98:327-33 |
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