A chronic rat system will be developed suitable for electrophysiological investigations of the aging brain, It will have an array of microelectrodes whose lengths are adjustable during manufacture so that the 3-D distribution of the electrode tips can be arranged to match the 3-D architecture of the cortical feature under study. This system will offer a unique opportunity to investigate in behaving rats the effect of aging on cortical information processing in a way not possible with current techniques. In addition to benefiting directly the aging research community, the tools and techniques resulting from Phases I and II will be applicable to many other programs using electrophysiological recordings from awake, behaving rats. Phase I develops the two key components: (1) a technique for making a 0.4-mm pitch microelectrode array structure where the lengths of individual electrodes can be between 0.5mm and 3.0mm, and (2) a 25-channel percutaneous connector. Chronic experiments will verify the biocompatibility of the connector and its fixation technique. Acute experiments will verify that the multielectrode array can record spontaneous neural activity in rat hippocampus. Phase II will optimize and validate the chronic system for implantation in rat hippocampus and demonstrate the relevance of electrophysiological findings in rat hippocampus to the aging process.

Proposed Commercial Applications

A chronic microelectrode array system will be marketed that is suitable for implantation in rats to study the electrophysiologic aspects of aging. It will also be marketed to researchers for investigating other cortical processes in rats.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43AG018711-01A1
Application #
6335609
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (10))
Program Officer
Huerta, Michael F
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
1
Fiscal Year
2001
Total Cost
$104,954
Indirect Cost
Name
Bionic Technologies, Inc.
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84108