The long-term objectives of this research is to develop improved permanent soft denture lining materials suitable for clinical applications. In Phase I, the physical properties of the new materials were studied as functions of material formulations. Hardness, elongation, tensile strength, tear strength, bonding strength to denture base polymers, water sorption and solubility, the leaching of monomers from the cured specimen, the capability of the new materials to inhibit the growth of Candida albicans, and the polishability of the cured materials were investigated. In Phase II, the optimization of the material formulation and processing methods will be further investigated. Both clinical prosthesis fabrication processes and polishing techniques for the new lining materials will be developed. Clinical prostheses will be fabricated using the nearly optimized materials and processes, and clinical serviceability of the new lining materials will be evaluated and compared with the control Molloplast-B.

Proposed Commercial Applications

Potential commercial applications of the research is the development of improved soft denture lining material which have permanent resiliency, good bonding to the denture base polymer, low water sorption and solubility, and are suitable for clinical applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DE011638-03
Application #
6176702
Study Section
Special Emphasis Panel (ZDE1-PW (51))
Program Officer
Kousvelari, Eleni
Project Start
1997-06-01
Project End
2001-11-30
Budget Start
2000-06-01
Budget End
2001-11-30
Support Year
3
Fiscal Year
2000
Total Cost
$285,461
Indirect Cost
Name
Lai Laboratories, Inc.
Department
Type
DUNS #
City
Burnsville
State
MN
Country
United States
Zip Code
55337
Brosky, Mary E; Pesun, Igor J; Morrison, Brad et al. (2003) Clinical evaluation of resilient denture liners. Part 2: Candida count and speciation. J Prosthodont 12:162-7
Villar, Anamaria; Pesun, Igor J; Brosky, Mary E et al. (2003) Clinical evaluation of a new resilient denture liner. Part 1: Compliance and color evaluation. J Prosthodont 12:82-9
Brosky, M E; Major, R J; DeLong, R et al. (2003) Evaluation of dental arch reproduction using three-dimensional optical digitization. J Prosthet Dent 90:434-40
Pesun, I J; Villar, A; Hodges, J S et al. (2001) Development of a nondestructive compliance test for resilient denture liners. J Prosthodont 10:91-6