A large, persuasive, and ever-increasing body of evidence links chronic inflammation to virtually all of the chronic diseases that cause the majority of disability and death in the U.S., including diabetes, cardiovascular diseases (CVD), and cancer. Diet plays a central role in the regulation of chronic inflammation. However, until we developed the dietary inflammatory index (DII) there had been no scientifically valid way to relate what individuals eat to the capacity of foods consumed to modulate inflammation. The new generation DII has now produced an impressive research base that ranges from predicting blood levels of inflammatory markers, to clinical conditions associated with inflammation, to a variety of health-related endpoints including cancer incidence and mortality. Connecting Health Innovations (CHI) and our scientific and clinical research partners at the University of South Carolina are committed to translating these research findings to places of clinical need and

Public Health Relevance

Although we know both that chronic, systemic inflammation is linked to virtually all of the chronic diseases that cause the majority of disability and death in he U.S., and that diet plays a central role in the regulation of chronic inflammation, there is virtualy no data linking all three factors. With our development of the dietary inflammatory index (DII) we have been able to fill this void. The work proposed here will allow us to translate an impressive body of evidence-based results linking diet, inflammation, and health-related endpoints to places of clinical need and public health relevance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
1R44DK103377-01
Application #
8779799
Study Section
Special Emphasis Panel (ZRG1-HDM-W (10))
Program Officer
Densmore, Christine L
Project Start
2014-09-04
Project End
2015-02-28
Budget Start
2014-09-04
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$304,339
Indirect Cost
Name
Connecting Health Innovations, LLC
Department
Type
DUNS #
078763657
City
Columbia
State
SC
Country
United States
Zip Code
29206
Mazul, Angela L; Shivappa, Nitin; Hébert, James R et al. (2018) Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer. Int J Cancer :
Shivappa, Nitin; Hébert, James R; Akhoundan, Mahdieh et al. (2018) Association between inflammatory potential of diet and odds of gestational diabetes mellitus among Iranian women. J Matern Fetal Neonatal Med :1-7
Shin, Dayeon; Kwon, Simona C; Kim, Mi Hye et al. (2018) Inflammatory potential of diet is associated with cognitive function in an older adult Korean population. Nutrition 55-56:56-62
Shivappa, Nitin; Niclis, Camila; Coquet, Julia Becaria et al. (2018) Increased inflammatory potential of diet is associated with increased odds of prostate cancer in Argentinian men. Cancer Causes Control 29:803-813
Shivappa, Nitin; Wirth, Michael D; Murphy, E Angela et al. (2018) Association between the Dietary Inflammatory Index (DII) and urinary enterolignans and C-reactive protein from the National Health and Nutrition Examination Survey-2003-2008. Eur J Nutr :
Shivappa, Nitin; Godos, Justyna; Hébert, James R et al. (2018) Dietary Inflammatory Index and Cardiovascular Risk and Mortality-A Meta-Analysis. Nutrients 10:
Zheng, Jiali; Merchant, Anwar T; Wirth, Michael D et al. (2018) Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Int J Cancer 142:2461-2470
Zheng, Jiali; Tabung, Fred K; Zhang, Jiajia et al. (2018) Association between Post-Cancer Diagnosis Dietary Inflammatory Potential and Mortality among Invasive Breast Cancer Survivors in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev 27:454-463
Sen, S; Rifas-Shiman, S L; Shivappa, N et al. (2018) Associations of prenatal and early life dietary inflammatory potential with childhood adiposity and cardiometabolic risk in Project Viva. Pediatr Obes 13:292-300
Assmann, Karen E; Adjibade, Moufidath; Shivappa, Nitin et al. (2018) The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults. J Nutr 148:437-444

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