A large, persuasive, and ever-increasing body of evidence links chronic inflammation to virtually all of the chronic diseases that cause the majority of disability and death in the U.S., including diabetes, cardiovascular diseases (CVD), and cancer. Diet plays a central role in the regulation of chronic inflammation. However, until we developed the dietary inflammatory index (DII) there had been no scientifically valid way to relate what individuals eat to the capacity of foods consumed to modulate inflammation. The new generation DII has now produced an impressive research base that ranges from predicting blood levels of inflammatory markers, to clinical conditions associated with inflammation, to a variety of health-related endpoints including cancer incidence and mortality. Connecting Health Innovations (CHI) and our scientific and clinical research partners at the University of South Carolina are committed to translating these research findings to places of clinical need and

Public Health Relevance

Although we know both that chronic, systemic inflammation is linked to virtually all of the chronic diseases that cause the majority of disability and death in he U.S., and that diet plays a central role in the regulation of chronic inflammation, there is virtualy no data linking all three factors. With our development of the dietary inflammatory index (DII) we have been able to fill this void. The work proposed here will allow us to translate an impressive body of evidence-based results linking diet, inflammation, and health-related endpoints to places of clinical need and public health relevance.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
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Special Emphasis Panel (ZRG1-HDM-W (10))
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Densmore, Christine L
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Connecting Health Innovations, LLC
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Mazul, Angela L; Shivappa, Nitin; Hébert, James R et al. (2018) Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer. Int J Cancer :
Shivappa, Nitin; Hébert, James R; Akhoundan, Mahdieh et al. (2018) Association between inflammatory potential of diet and odds of gestational diabetes mellitus among Iranian women. J Matern Fetal Neonatal Med :1-7
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Shivappa, Nitin; Niclis, Camila; Coquet, Julia Becaria et al. (2018) Increased inflammatory potential of diet is associated with increased odds of prostate cancer in Argentinian men. Cancer Causes Control 29:803-813
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Zheng, Jiali; Tabung, Fred K; Zhang, Jiajia et al. (2018) Association between Post-Cancer Diagnosis Dietary Inflammatory Potential and Mortality among Invasive Breast Cancer Survivors in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev 27:454-463
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Assmann, Karen E; Adjibade, Moufidath; Shivappa, Nitin et al. (2018) The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults. J Nutr 148:437-444

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