This is a proposal to design and construct a pulsed X-ray 2D imaging system which would rotate around the patient at high speed (approximately four seconds for 120 degrees) to acquire a rotational view of a vessel during an angiographic injection. The unit cannot be slower than four seconds due to contrast media transit time, and the fact that capillary phase and/or venous return begins at about four seconds for most arterial injections. All imaging is sequential, at 30 or 60 FPS. The proposal is based on a Phase I study that has determined that geometric blurring due to the X-ray focal spot, and motion blurring due to heart motion are still the predominant factors for the geometry described in the Phase I study; that would still be true even for a two second scan. It should be possible to visualize 600 micron vessels during a rotational angiographic sequence, and that is the design goal. Computer reconstruction is not needed as the images are viewed directly.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44HL046578-03
Application #
2223066
Study Section
Special Emphasis Panel (SSS (B4))
Project Start
1991-06-01
Project End
1996-08-31
Budget Start
1994-09-01
Budget End
1996-08-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Xre Corporation
Department
Type
DUNS #
City
Littleton
State
MA
Country
United States
Zip Code
01460