Understanding the brain remains a great challenge both to professional neuroscientists and the general public alike. The nervous system is extremely complex, which is why neural diseases are notoriously widespread and difficult to treat. There are two main ways to solve this problem. One approach is to fund established scientists to research their particular field of study. An alternative way is to invest in the capabilities of future engineers, scientists, and physicians by providing educational science equipment and compelling experiments that teach principles of neuroscience using simple model organisms. A critical barrier to progress with this latter approach has been access to affordable tools and lesson plans. To address this need, we have developed in our Phase I the 1) """"""""SpikerBox"""""""": a bio-amplifier that is easy-to-use, inexpensive (<$100), portable, and can detect and record the spiking activity (action potentials) of invertebrates such as crickets and cockroaches;and the 2) """"""""RoboRoach"""""""": a wireless neural stimulator for investigating insect behavior. We have designed easy experiments using these pieces of equipment and have begun deploying them in beta high school test sites. In Phase II, we now aim to: 1. Enhance the learning materials and software to the degree that allows any high school biology teacher with little experience to teach neurophysiology experiments in the classroom 2. Commercialize and deploy the next generation RoboRoach and SpikerBox to allow for a greater versatility in experiments for high school classrooms 3. Commercialize and deploy our """"""""OptoGenetics Rig,"""""""" which is a fully portably miniature electrophysiology apparatus enabling optogenetic experiments in fruit flies in high school classrooms As neuroscience is a multi-disciplinary field encompassing biology, medicine, mathematics, and engineering, our """"""""SpikerBox"""""""", """"""""RoboRoach"""""""", and """"""""Optogenetic"""""""" kits with their associated learning materials may have the effect of improving performance in STEM-related disciplines and inspiring the next generation of scientists and engineers. !

Public Health Relevance

Backyard Brains will commercialize the SpikerBox, RoboRoach, and Optogenetic kits with associated learning materials and software to allow secondary school students to investigate the living nervous system of insects in the classroom. By allowing these students to do what was previously only available in advanced college, we aim to inspire the next generation of scientists, physicians, and engineers as well as accelerate fundamental neuroscience research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44MH093334-04
Application #
8641417
Study Section
Special Emphasis Panel ()
Program Officer
Grabb, Margaret C
Project Start
2011-04-15
Project End
2016-03-31
Budget Start
2014-04-08
Budget End
2015-03-31
Support Year
4
Fiscal Year
2014
Total Cost
$599,521
Indirect Cost
Name
Backyard Brains, Inc.
Department
Type
DUNS #
829881866
City
Ann Arbor
State
MI
Country
United States
Zip Code
48104
Marzullo, Timothy C (2017) The Missing Manuscript of Dr. Jose Delgado's Radio Controlled Bulls. J Undergrad Neurosci Educ 15:R29-R35
Nuñez, Isaac; Matute, Tamara; Herrera, Roberto et al. (2017) Low cost and open source multi-fluorescence imaging system for teaching and research in biology and bioengineering. PLoS One 12:e0187163
Nguyen, Dieu My T; Roper, Mark; Mircic, Stanislav et al. (2017) Grasshopper DCMD: An Undergraduate Electrophysiology Lab for Investigating Single-Unit Responses to Behaviorally-Relevant Stimuli. J Undergrad Neurosci Educ 15:A162-A173
Marzullo, Timothy C (2016) Leg Regrowth in Blaberus discoidalis (Discoid Cockroach) following Limb Autotomy versus Limb Severance and Relevance to Neurophysiology Experiments. PLoS One 11:e0146778
Baden, Tom; Chagas, Andre Maia; Gage, Gregory J et al. (2015) Open Labware: 3-D printing your own lab equipment. PLoS Biol 13:e1002086
Baden, Tom; Chagas, Andre Maia; Gage, Gregory J et al. (2015) Correction: open labware: 3-d printing your own lab equipment. PLoS Biol 13:e1002175
Shannon, Kyle M; Gage, Gregory J; Jankovic, Aleksandra et al. (2014) Portable conduction velocity experiments using earthworms for the college and high school neuroscience teaching laboratory. Adv Physiol Educ 38:62-70
Dagda, Ruben K; Thalhauser, Rachael M; Dagda, Raul et al. (2013) Using crickets to introduce neurophysiology to early undergraduate students. J Undergrad Neurosci Educ 12:A66-74
Marzullo, Timothy C; Gage, Gregory J (2012) The SpikerBox: a low cost, open-source bioamplifier for increasing public participation in neuroscience inquiry. PLoS One 7:e30837