This proposal describes a pre-and postdoctoral training program in immunology centered at the University of California, San Diego (UCSD). It provides a training focus in immunology for select students from the broad pre-doctoral programs in the Division of Biological Sciences and the School of Medicine. It will provide resources and organization for the training of postdoctoral fellows in the laboratories of participating faculty located at the UCSD School of Medicine, The UCSD Division of Biological Sciences, and the La Jolla Institute for Allergy and Immunology (LIAI). The training program is designed to leverage the rich resources and faculty expertise in existence at UCSD including: the San Diego Supercomputer Center; clinical immunology at the UCSD School of Medicine; and the basic science programs located at the School of Medicine, the Division of Biological Sciences, and the LIAI. The training program will include many aspects of immunology as broadly defined, but in course-work and seminars, emphasis will be place on the regulation of immunity as it applies to infectious diseases and the immunopathology associated with an over exuberant immune response. ? ? ?

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Application #
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
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Szumowski, Suzannah C; Estes, Kathleen A; Popovich, John J et al. (2016) Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Cell Microbiol 18:30-45
Lewis, Gavin M; Macal, Monica; Hesser, Charles R et al. (2015) Constitutive but not inducible attenuation of transforming growth factor ? signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral infection. J Virol 89:3343-55
Borkowski, Andrew W; Kuo, I-Hsin; Bernard, Jamie J et al. (2015) Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 135:569-578
Borkowski, Andrew W; Park, Kyungho; Uchida, Yoshikazu et al. (2013) Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles. J Invest Dermatol 133:2031-40
Best, J Adam; Blair, David A; Knell, Jamie et al. (2013) Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol 14:404-12
van Sorge, Nina M; Beasley, Federico C; Gusarov, Ivan et al. (2013) Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem 288:6417-26
Ruff, Laura E; Mahmoud, Enas A; Sankaranarayanan, Jagadis et al. (2013) Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb) 5:195-203
Lefort, Craig T; Rossaint, Jan; Moser, Markus et al. (2012) Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood 119:4275-82
Rillahan, Cory D; Antonopoulos, Aristotelis; Lefort, Craig T et al. (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol 8:661-8
Bezman, Natalie A; Kim, Charles C; Sun, Joseph C et al. (2012) Molecular definition of the identity and activation of natural killer cells. Nat Immunol 13:1000-9

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