Abstract

This proposal describes a pre-and postdoctoral training program in immunology centered at the University of California, San Diego (UCSD). It provides a training focus in immunology for select students from the broad pre-doctoral programs in the Division of Biological Sciences and the School of Medicine. It will provide resources and organization for the training of postdoctoral fellows in the laboratories of participating faculty located at the UCSD School of Medicine, The UCSD Division of Biological Sciences, and the La Jolla Institute for Allergy and Immunology (LIAI). The training program is designed to leverage the rich resources and faculty expertise in existence at UCSD including: the San Diego Supercomputer Center;clinical immunology at the UCSD School of Medicine;and the basic science programs located at the School of Medicine, the Division of Biological Sciences, and the LIAI. The training program will include many aspects of immunology as broadly defined, but in course-work and seminars, emphasis will be place on the regulation of immunity as it applies to infectious diseases and the immunopathology associated with an over exuberant immune response.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060536-04
Application #
7618029
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2006-07-01
Project End
2011-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
4
Fiscal Year
2009
Total Cost
$243,330
Indirect Cost

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Szumowski, Suzannah C; Estes, Kathleen A; Popovich, John J et al. (2016) Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Cell Microbiol 18:30-45
Lewis, Gavin M; Macal, Monica; Hesser, Charles R et al. (2015) Constitutive but not inducible attenuation of transforming growth factor ? signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral infection. J Virol 89:3343-55
Borkowski, Andrew W; Kuo, I-Hsin; Bernard, Jamie J et al. (2015) Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 135:569-578
Borkowski, Andrew W; Park, Kyungho; Uchida, Yoshikazu et al. (2013) Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles. J Invest Dermatol 133:2031-40
Best, J Adam; Blair, David A; Knell, Jamie et al. (2013) Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol 14:404-12
van Sorge, Nina M; Beasley, Federico C; Gusarov, Ivan et al. (2013) Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem 288:6417-26
Ruff, Laura E; Mahmoud, Enas A; Sankaranarayanan, Jagadis et al. (2013) Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb) 5:195-203
Cole, Jason N; Aziz, Ramy K; Kuipers, Kirsten et al. (2012) A conserved UDP-glucose dehydrogenase encoded outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus. J Bacteriol 194:6154-61
Gu, Luo; Ruff, Laura E; Qin, Zhengtao et al. (2012) Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater 24:3981-7
Lefort, Craig T; Rossaint, Jan; Moser, Markus et al. (2012) Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood 119:4275-82

Showing the most recent 10 out of 16 publications