In this resubmission, we request support for two graduate trainees selected each year, who have attained dissertator status in our predoctoral Columbia University Graduate Training Program in Microbiology and Immunology. Each trainee would be funded for two years. This PhD granting Program, led by our Director Dr. David Fidock and Co-Director Dr. Boris Reizis, provides predoctoral trainees with a unique opportunity to obtain individualized training across a broad spectrum of microbiology and immunology research. This research converges on themes of immune cell and tissue development and homeostasis, pathogen biology, mechanisms of DNA replication and repair, and microbial and immune cell proliferation. These cross-disciplinary interests are being pursued in a highly collaborative and interactive framework that links our 19 training faculty, who are all appointed to the Department of Microbiology &Immunology, led by our Chairman Dr. Sankar Ghosh. Our graduate program, built on many decades of successful graduate training, has proven that we can recruit and retain an outstanding cohort of training grant eligible (TGE) applicants. Trainees take courses in microbiology and immunology, biochemistry, molecular cell biology, genetics, quantitative biology, and responsible conduct in research, and are enrolled in workshops on scientific writing and grantsmanship. Students must also pass a qualifying examination that tests their ability to formulate and defend a hypothesis-driven project unrelated to their thesis research. Our programmatic framework includes a Steering Committee that regularly evaluates student and trainer performance, the curriculum, and new applicants;a process to identify the best trainees and mentor them successfully throughout their graduate studies;a mentoring plan for junior trainers, and an External Review Board with Program Directors who provide regular feedback to help optimize program effectiveness. Our Graduate Program has shown excellent recruitment and retention rates, along with an outstanding record of career outcomes for former predoctoral trainees, including underrepresented minorities or disadvantaged students. 95% of our former trainees in the past decade have continued in science or medicine and 15% have already achieved tenure-track or non tenure-track faculty positions. Our increased emphasis on recruitment of underrepresented minorities includes a new agreement with the University of Puerto Rico, which has a large student body of TGE applicants, and extensive outreach initiatives. We also benefit from very strong institutional support provided by the Dean of our medical school and our Office of Graduate Affairs, including financial support that allows our training grant to support selected trainees once they have successfully completed their coursework and qualifying examination and are engaged in full-time research. We are confident that our dynamic, rigorous and scientifically innovative training program will mold future academic leaders in microbiology and immunology research who will have acquired the skills to be able to tackle critical topics in infectious diseases and immune regulation.

Public Health Relevance

This resubmitted application for NIH support of the Columbia University Graduate Training Program in Microbiology and Immunology is relevant to the public health mission of NIAID in its proposal to fund research into microorganisms that can cause disease and the immune responses that are mounted to counter these infections. We will further investigate how microbes survive and grow, using model non-infectious organisms, and study immune parameters that dictate non-infectious diseases such as donor organ rejection and B-cell lymphoma. Our predoctoral trainees will be trained in state of the art research skills that build on a strong foundation of life sciences graduate course work. Our PhD program is designed to provide our trainees with the skills and knowledge needed to become future innovators in microbiology and immunology research and contribute to the NIH mission to improve human health through scientific research.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAI1-JTS-I (M2))
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Prograis, Lawrence J
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Columbia University
Schools of Medicine
New York
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