Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009104-13
Application #
3532454
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1975-07-01
Project End
1990-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
13
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Tennessee Knoxville
Department
Type
Graduate Schools
DUNS #
City
Knoxville
State
TN
Country
United States
Zip Code
37996
Preston, G A; Payne, H S; Preston, R J (1992) Isolation and characterization of a 1-beta-D-arabinofuranosylcytosine-resistant Chinese hamster ovary cell mutant that is also X-ray sensitive and is noncomplementary with ataxia telangiectasia cells. Cancer Res 52:319-27
Engler, D A; Campion, S R; Hauser, M R et al. (1992) Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation. J Biol Chem 267:2274-81
Ford, V A; Stringer, C; Kennel, S J (1992) Thrombomodulin is preferentially expressed in Balb/c lung microvessels. J Biol Chem 267:5446-50
Matsunami, R K; Yette, M L; Stevens, A et al. (1991) Mutational analysis of leucine 47 in human epidermal growth factor. J Cell Biochem 46:242-9
Engler, D A; Hauser, M R; Cook, J S et al. (1991) Aromaticity at position 37 in human epidermal growth factor is not obligatory for activity. Mol Cell Biol 11:2425-31
Matsunami, R K; Campion, S R; Niyogi, S K et al. (1990) Analogs of human epidermal growth factor which partially inhibit the growth factor-dependent protein-tyrosine kinase activity of the epidermal growth factor receptor. FEBS Lett 264:105-8
Engler, D A; Montelione, G T; Niyogi, S K (1990) Human epidermal growth factor. Distinct roles of tyrosine 37 and arginine 41 in receptor binding as determined by site-directed mutagenesis and nuclear magnetic resonance spectroscopy. FEBS Lett 271:47-50
Campion, S R; Matsunami, R K; Engler, D A et al. (1990) Biochemical properties of site-directed mutants of human epidermal growth factor: importance of solvent-exposed hydrophobic residues of the amino-terminal domain in receptor binding. Biochemistry 29:9988-93
Tindal, M H; Lee, K L; Isham, K R et al. (1988) Structure of a multihormonally regulated rat gene. Gene 71:413-20
Engler, D A; Matsunami, R K; Campion, S R et al. (1988) Cloning of authentic human epidermal growth factor as a bacterial secretory protein and its initial structure-function analysis by site-directed mutagenesis. J Biol Chem 263:12384-90

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