This proposal requests continued funding for the Cellular and Molecular Basis of Disease (CMBD) Training Program at Northwestern University. The CMBD program supports comprehensive pre-doctoral graduate training in the life sciences, focusing on the cellular, molecular and biochemical mechanisms used in biological systems and targeted in diseases impacting human health. The CMBD program has provided intradepartmental and interdisciplinary training opportunities for Northwestern life science graduate students for the past 30 years, and has been a centerpiece for cross campus interactions at Northwestern. CMBD trainees are selected primarily from two integrated interdepartmental programs: the Interdepartmental Biological Sciences Graduate Program (IBiS) on the Evanston campus and the Driskill Graduate Training Program in the Life Sciences (DGP) on the Chicago Medical School campus. Students are appointed in the spring quarter of their second year, after they have completed their core coursework and joined their dissertation research laboratories, and they are typically supported for two or three years. As a University-wide training program with 18 trainee positions and a broad spectrum of faculty, CMBD has taken a leadership role in fostering communication and collaboration between researchers on the two campuses, and many collaborative interactions have arisen directly from the monthly student- oriented CMBD Research in Progress meetings. CMBD also facilitates student interactions with scientists at other institutions, both by providing the opportunity for CMBD trainees to present their research at national meetings and conferences, and by bringing outstanding research scientists to Northwestern, through the CMBD seminar and symposia programs. CMBD provides for training of students in the ethical conduct of research, and offers trainees the opportunity to participate in several outstanding career development forums at Northwestern University, most prominently the """"""""Bio- Opportunities"""""""" program. Graduates of the CMBD program have continued as successful and productive scientists at many other institutions and in diverse careers, contributing in important ways to cell and molecular biology research on a national level.
The CMBD training program brings together a community of trainees and mentors whose expertise spans the range from basic to translational research. By fostering communication among these researchers, participants develop a deeper appreciation of how different areas of study relate to one another and how to apply the principles from different disciplines to better integrate biomedical research.
|Gonen, Nitzan; Futtner, Chris R; Wood, Sophie et al. (2018) Sex reversal following deletion of a single distal enhancer of Sox9. Science 360:1469-1473|
|Bagchi, Sreya; Genardi, Samantha; Wang, Chyung-Ru (2018) Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter. Front Immunol 9:1616|
|Quillin, Sarah J; Hockenberry, Adam J; Jewett, Michael C et al. (2018) Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response. mSystems 3:|
|Parisien, Jean-Patrick; Lenoir, Jessica J; Mandhana, Roli et al. (2018) RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling. EMBO Rep 19:|
|Pesce, C Gustavo; Zdraljevic, Stefan; Peria, William J et al. (2018) Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling. Mol Syst Biol 14:e7390|
|Kaplan, Nihal; Ventrella, Rosa; Peng, Han et al. (2018) EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Invest Ophthalmol Vis Sci 59:393-406|
|Evans, Kathryn S; Brady, Shannon C; Bloom, Joshua S et al. (2018) Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses. Genetics 210:1509-1525|
|Hughes, A J; Knoten, C A; Morris, A R et al. (2018) ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa. J Med Microbiol 67:1168-1180|
|Daniel, Gina R; Pegg, Caitlin E; Smith, Gregory A (2018) Dissecting the Herpesvirus Architecture by Targeted Proteolysis. J Virol 92:|
|Garcia-Moreno, S Alexandra; Plebanek, Michael P; Capel, Blanche (2018) Epigenetic regulation of male fate commitment from an initially bipotential system. Mol Cell Endocrinol 468:19-30|
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