We propose a training program in clinical pharmacology that integrates the strengths of the David Geffen School of Medicine at UCLA, the seventh largest recipient of NIH funding, the UCLA Medical Center, consistently ranked among the Top 5 nationwide and best in the West, and Charles Drew University, a historically black medical school. Our program has been created specifically to develop academic leaders and independently funded investigators in clinical pharmacology. Under the leadership of the PI, a Hispanic physician-scientist working in the area of pharmacogenomics, we have established a focus on clinical pharmacology in minorities, special populations, and career development efforts that are highly inclusive of members of underrepresented groups. We will provide rigorous, multidisciplinary postdoctoral research training with an emphasis on hypothesis-driven laboratory or clinical research that addresses the effects and mechanisms of drug actions in humans. We organized the faculty in 2 groups, in order to create a broad and diverse training program that is cohesive and focused. The first is a core group consisting of 6 members who are highly committed to teaching and career development in clinical pharmacology. The second group consists of 46 faculty members from 8 basic science departments and 11 clinical departments or divisions. They are experts in basic, translational, or clinical investigation that addresses key issues in clinical pharmacology and who will be potential mentors for trainees. We expect that 75% of trainees will be M.D.s. To ensure a broad representation of basic science and clinical research, we obtained letters of support from the following academic leaders at UCLA: 6 basic science chairpersons, 9 clinical chairpersons, 8 clinical division heads, and 3 key academic leaders at Drew: the Chairman of Medicine and the Associate Deans for Research and Education. Those letters document the commitment to identify highly qualified individuals for this program. Moreover, we have a proven track record in recruiting outstanding trainees for our K12, K30, and Master's Programs, which also provide instruction in clinical pharmacology. The training experience will be enhanced by a rich didactic program that will be taught by faculty from UCLA as well as visiting faculty who are nationally recognized for their contributions to clinical pharmacology. ? ?

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Okita, Richard T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Schools of Medicine
Los Angeles
United States
Zip Code
Calkins, Kara L; DeBarber, Andrea; Steiner, Robert D et al. (2017) Intravenous Fish Oil and Pediatric Intestinal Failure-Associated Liver Disease: Changes in Plasma Phytosterols, Cytokines, and Bile Acids and Erythrocyte Fatty Acids. JPEN J Parenter Enteral Nutr :148607117709196
Calkins, Kara L; Havranek, Thomas; Kelley-Quon, Lorraine I et al. (2017) Low-Dose Parenteral Soybean Oil for the Prevention of Parenteral Nutrition-Associated Liver Disease in Neonates With Gastrointestinal Disorders. JPEN J Parenter Enteral Nutr 41:404-411
Levit, Orly L; Calkins, Kara L; Gibson, L Caroline et al. (2016) Low-Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates. JPEN J Parenter Enteral Nutr 40:374-82
Xia, Mingcan; Viera-Hutchins, Loida; Garcia-Lloret, Maria et al. (2015) Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol 136:441-53
Calkins, Kara L; Venick, Robert S; Devaskar, Sherin U (2014) Complications associated with parenteral nutrition in the neonate. Clin Perinatol 41:331-45
Calkins, Kara; Lowe, Allison; Shew, Stephen B et al. (2013) Short-term intravenous fish oil and pediatric intestinal failure associated liver disease: 3-year follow-up on liver function and nutrition. J Pediatr Surg 48:228-32
Balan, Irina S; Saladino, Andrew J; Aarabi, Bizhan et al. (2013) Cellular alterations in human traumatic brain injury: changes in mitochondrial morphology reflect regional levels of injury severity. J Neurotrauma 30:367-81
Kristian, Tibor; Balan, Irina; Schuh, Rosemary et al. (2011) Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection. J Neurosci Res 89:1946-55
Hoang, Phuong T; Park, Patricia; Cobb, Laura J et al. (2010) The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism 59:343-9
Balan, Irina S; Fiskum, Gary; Kristian, Tibor (2010) Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique. Brain Res 1316:112-9