Plants convert sunlight into chemical energy, allowing them to synthesize the organic compounds needed to sustain human life on earth; thus plants provide essential nutrients, medicines, shelter and energy. As human culture has progressed, we have utilized plants in increasingly sophisticated ways, progressing from breeding- based agriculture through discovery of modern medicines and most recently using biotechnology. We now look to plants to address global issues such as the sustainable production of fuels to mitigate the environmental impacts of fossil fuels. Plant diversity is enormous and relatively litte of the chemical repertoire of plants has been recognized and utilized. Plant biotechnology has the potential to meet many of the current challenges threatening human wellbeing, but maintaining or improving the health of a growing world population against a backdrop of a changing environment will require that plant scientists receive innovative and cross-disciplinary training. The goal of the Plant Biotechnology for Health and Sustainability (PBHS) predoctoral training program is to foster the education, training, and professional development of the next generation of interdisciplinary scientists who will assume leadership positions in health and sustainability-related biotechnology careers, including academia, industry, government, and entrepreneurship. A set of core competencies will be emphasized including integrating a broad set of content areas related to health and reduced environmental impacts, developing critical thinking, and honing communication skills essential for effective collaboration across disciplines. Trainees will be exposed to the full biotechnology pipeline from basic research to commercialization. Emphasis will be placed on building specific skill sets designed to promote personal and professional development and provide a basis for evaluation of trainee performance. Bachelor's and master's degree level trainees will enter the PBHS program at the end of the second semester of predoctoral training. During the second year of predoctoral work, trainees will take three courses that introduce concepts in plant biotechnology, collaborative and quantitative research and that describe paths for translation of basic research into commercial products. The program will provide stipends to three to seven students at a time for two years each; these NRSA-funded students will be joined by one to two Michigan State University Graduate School-funded students.

Public Health Relevance

Plants play a central role in public health by providing calories, nutrients and medicines for humans and the animals that we rely on for our wellbeing. Rapid human population growth and dietary changes in make it increasingly important to develop new approaches to harness plants and photosynthetic microbes to improve human health in an environmentally sustainable way. These '21st Century' approaches to improving human health and environmental wellbeing will require a biotechnology workforce with a new set of cross- disciplinary technical skills and an understanding of the full biotechnology pipeline from discovery to commercialization.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM110523-05
Application #
9518957
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Brown, Patrick
Project Start
2014-07-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Michigan State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Agostoni, Marco; Logan-Jackson, AlshaƩ R; Heinz, Emily R et al. (2018) Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress. Front Microbiol 9:1121
Xu, Haiyang; Lybrand, Daniel; Bennewitz, Stefan et al. (2018) Production of trans-chrysanthemic acid, the monoterpene acid moiety of natural pyrethrin insecticides, in tomato fruit. Metab Eng 47:271-278
Angelos, Evan; Brandizzi, Federica (2018) NADPH oxidase activity is required for ER stress survival in plants. Plant J 96:1106-1120
Duhl, Kody L; Tefft, Nicholas M; TerAvest, Michaela A (2018) Shewanella oneidensis MR-1 Utilizes both Sodium- and Proton-Pumping NADH Dehydrogenases during Aerobic Growth. Appl Environ Microbiol 84:
Medina-Cucurella, Angelica V; Whitehead, Timothy A (2018) Characterizing Protein-Protein Interactions Using Deep Sequencing Coupled to Yeast Surface Display. Methods Mol Biol 1764:101-121
Angelos, Evan; Ruberti, Cristina; Kim, Sang-Jin et al. (2017) Maintaining the factory: the roles of the unfolded protein response in cellular homeostasis in plants. Plant J 90:671-682
Leong, Bryan J; Last, Robert L (2017) Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism. Curr Opin Struct Biol 47:105-112
Klesmith, Justin R; Bacik, John-Paul; Wrenbeck, Emily E et al. (2017) Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning. Proc Natl Acad Sci U S A 114:2265-2270
Wrenbeck, Emily E; Faber, Matthew S; Whitehead, Timothy A (2017) Deep sequencing methods for protein engineering and design. Curr Opin Struct Biol 45:36-44
Clark, Teresa J; Friel, Colleen A; Grman, Emily et al. (2017) Modelling nutritional mutualisms: challenges and opportunities for data integration. Ecol Lett 20:1203-1215

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