This is a renewal application of a training program in its 9th year that seeks funding to support predoctoral and postdoctoral research trainees in a multidisciplinary research program in cardiovascular and vascular diseases spanning from molecular and cellular studies, imaging, biomedical engineering, to translational science. During the last funding cycle, we have been highly successful in expanding our training program from 31 faculty five years ago to 40 faculty in this competing renewal. The faculty in our Training Program are from five different schools/Colleges. Indeed, the training program has had a highly synergistic impact on our institution; we have been successful in establishing a new Cardiovascular Research Center (CVRC) through institutional funding from five different schools and colleges at UC Davis which will be launched in Fall 2017. The curriculum and activities developed within the training program have been used as models for other training grants in translational research on campus and hence, serve a wider group of trainees at UC Davis. The Program operates under the auspices of the Department of Internal Medicine and the Graduate Studies in Molecular, Cellular and Integrative Physiology (MCIP), Pharmacology and Toxicology (PTX), Biochemistry, Molecular, Cellular and Developmental Biology (BMCDB), Biophysics (BPH) and Biomedical Engineering (BME), a truly multidisciplinary program. The goal of the Training Program is to produce a new blend of scientists who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research. The advantages of such an integrated program are vast and far reaching. By merging clinical mentors together with pre-doctoral and post-doctoral trainees in basic science, our objectives are to foster new Ph.D.s and postdoctoral researchers who are not only capable of establishing independent research, but are also adept to recognizing and integrating relevant basic science questions into clinically germane answers and solutions.

Public Health Relevance

This goal of the Training Program is to produce a new blend of scientists in cardiovascular research who are poised to exchange ideas, expertise, and techniques leading to the direct and effective flow and translation of basic science discoveries into clinical testing and applications, as well as generate mechanistic hypotheses that can be tested at the basic cellular level, directly derived from clinical research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL086350-12
Application #
9628029
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Wang, Wayne C
Project Start
2008-03-01
Project End
2023-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California Davis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Tilley, Drew C; Angueyra, Juan M; Eum, Kenneth S et al. (2018) The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. J Gen Physiol :
Vorwald, Charlotte E; Murphy, Kaitlin C; Leach, J Kent (2018) Restoring vasculogenic potential of endothelial cells from diabetic patients through spheroid formation. Cell Mol Bioeng 11:267-278
Nieves-CintrĂ³n, Madeline; Syed, Arsalan U; Nystoriak, Matthew A et al. (2018) Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation 25:
Harris, Todd R; Kodani, Sean; Rand, Amy A et al. (2018) Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. Mol Pharmacol 94:834-841
Thai, Phung N; Daugherty, Daniel J; Frederich, Bert J et al. (2018) Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Sci Rep 8:16213
Zhang, Xiao-Dong; Coulibaly, Zana A; Chen, Wei Chun et al. (2018) Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep 8:4670
Nystoriak, Matthew A; Navedo, Manuel F (2018) Regulation of microvascular function by voltage-gated potassium channels: New tricks for an ""ancient"" dog. Microcirculation 25:
Vorwald, Charlotte E; Ho, Steve S; Whitehead, Jacklyn et al. (2018) High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels. Methods Mol Biol 1758:139-149
Nieves-CintrĂ³n, Madeline; Syed, Arsalan U; Buonarati, Olivia R et al. (2017) Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep 7:14058
Sirish, Padmini; Ledford, Hannah A; Timofeyev, Valeriy et al. (2017) Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol 10:

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