The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 27 trainers and 9 junior trainers from 6 basic science and 4 clinical affiliate programs at Case Western Reserve University. The recruited faculty is known for excellence in research, ample NIH funding, and robust research space. The training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Vascular development, inflammation, and thrombosis (b) Cardiac hypertrophy, failure, and regeneration, (c) Cardiac Electrophysiology and arrhythmias, (d) Metabolism and redox regulation, (e) Signal transduction and gene expression , and (f) Cardiovascular imaging. Predoctoral training is accomplished through enrollment of students who have already matriculated in PhD programs in Biomedical Engineering, Cell Biology, Molecular Medicine, Nutrition, Pharmacology, and Physiology &Biophysics, and who have selected a thesis advisor from among the participating trainers. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in the weekly seminar series, monthly journal club, and annual research retreat organized by the recently established Case Cardiovascular Research Institute (CVRI), and mentoring by a CRTP faculty committee that includes senior trainers and junior non-trainer faculty who are developing independent programs in cutting-edge areas of cardiovascular research. Postdoctoral trainees, who are appointed via their recruitment to CRTP trainer labs, also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. This application seeks 6 positions for years 1-2 (3 for predoctoral trainees and 3 postdoctoral trainees) and 8 positions for years 3-5 (4 predoctoral and 4 postdoctoral trainees).

Public Health Relevance

This Training Program is unique in offering discipline-based training in cardiovascular research within the context of a larger community of trainers from different disciplines who interact via the multiple programs and venues of the Case Cardiovascular Research Institute. Thus, all trainees are exposed to the diverse perspectives and investigational approaches that are critical to current cardiovascular research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Case Western Reserve University
Internal Medicine/Medicine
Schools of Medicine
United States
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Chai, Sam; Wan, Xiaoping; Ramirez-Navarro, Angelina et al. (2018) Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity. J Clin Invest 128:1043-1056
Hsieh, Paishiun N; Sweet, David R; Fan, Liyan et al. (2017) Aging and the Kr├╝ppel-like factors. Trends Cell Mol Biol 12:1-15
Wilson, Kirkland A; Han, Yong; Zhang, Miaoqi et al. (2017) Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. Am J Physiol Endocrinol Metab 313:E413-E428
Hsieh, Paishiun N; Zhou, Guangjin; Yuan, Yiyuan et al. (2017) A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction. Nat Commun 8:914
Nassal, Drew M; Wan, Xiaoping; Liu, Haiyan et al. (2017) KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity. PLoS One 12:e0175221
Nassal, Drew M; Wan, Xiaoping; Liu, Haiyan et al. (2017) KChIP2 is a core transcriptional regulator of cardiac excitability. Elife 6:
Bruckman, Michael A; Czapar, Anna E; VanMeter, Allen et al. (2016) Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer. J Control Release 231:103-13
Russo, Hana M; Rathkey, Joseph; Boyd-Tressler, Andrea et al. (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol 197:1353-67
Pitek, Andrzej S; Wen, Amy M; Shukla, Sourabh et al. (2016) The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates. Small 12:1758-69
Lizotte, P H; Wen, A M; Sheen, M R et al. (2016) In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer. Nat Nanotechnol 11:295-303

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